Eczema and cardiovascular risk factors in 2 US adult population studies
Eczema and cardiovascular risk factors in 2 US adult population studies
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DOI：
10.1016/j.jaci.2014.11.023
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发表时间：
2015-03-01
影响因子：
14.2
通讯作者：
Greenland, Philip
中科院分区：
文献类型：
--
作者：
Silverberg, Jonathan I.;Greenland, Philip
背景：湿疹与睡眠障碍和生活质量受损的高发生率相关。这些因素可能对社会心理发展和行为产生负面影响，并可能增加心血管风险。目的：我们试图确定患有湿疹的成年人是否会增加心血管危险因素。方法：我们分析了 2010 年和 2012 年全国健康访谈调查中 27,157 名和 34,525 名 18 至 85 岁成年人的数据。结果：患有湿疹的成年人一生中吸过 100 支烟的几率更高（调查逻辑回归；调整比值比 [aOR]，1.32；95% CI，1.18-1.47）和当前吸烟史（aOR，1.28；95% CI，1.12-1.45），发病年龄明显较年轻（调查线性回归；调整 beta，-0.58；95% CI，-0.95 至 -0.21）。湿疹还与每年饮用 12 种或更多酒精饮料的几率较高相关（aOR，1.16；95% CI，1.03-1.31），包括当前摄入量中等（aOR，1.33；95% CI，1.09-1.62）和大量（aOR，1.58；95% CI，1.23-2.03）。与无湿疹病史的成年人相比，有湿疹病史的成年人每日剧烈活动的几率较低（aOR，0.79；95% CI，0.63-0.99），过去一周剧烈活动的频率也较低（调整后的 beta，-0.46；95% CI，-0.72 至 -0.21）。患有湿疹的人比没有湿疹的人有更高的体重指数（调整后的β，0.86；95% CI，0.37-1.36），特别是体重指数为35或更高（aOR，1.54；95% CI，1.16-2.05），并且患高血压的几率更高（aOR，1.48；95% CI， 1.18-1.85）、两次就诊高血压（aOR，1.56；1.22-1.99）和终生糖尿病前期（aOR，1.71；95% CI，1.19-2.45）。最后，湿疹和睡眠障碍之间存在显着的相互作用，例如与疲劳、白天嗜睡或失眠相关的湿疹与单纯湿疹相比，与肥胖、高血压、两次就诊高血压、糖尿病前期、糖尿病和高胆固醇的几率更高。结论：我们发现成人湿疹是心血管风险的一个标志，强调了行为改变的重要性，也许更积极的干预措施可以更好地控制湿疹。
Background: Eczema is associated with high rates of sleep disturbance and quality-of-life impairment. These factors might have a negative impact on psychosocial development and behavior and could increase cardiovascular risk.Objective: We sought to determine whether adults with eczema have increased cardiovascular risk factors.Methods: We analyzed data for 27,157 and 34,525 adults aged 18 to 85 years from the 2010 and 2012 National Health Interview Survey.Results: Adults with eczema had higher odds of ever smoking 100 cigarettes in their lifetime (survey logistic regression; adjusted odds ratio [aOR], 1.32; 95% CI, 1.18-1.47) and current smoking history (aOR, 1.28; 95% CI, 1.12-1.45), with significantly younger age of onset (survey linear regression; adjusted beta, -0.58; 95% CI, -0.95 to -0.21). Eczema was also associated with greater odds of ever drinking 12 or more alcoholic beverages annually (aOR, 1.16; 95% CI, 1.03-1.31), including current intake of moderate (aOR, 1.33; 95% CI, 1.09-1.62) and heavier (aOR, 1.58; 95% CI, 1.23-2.03) amounts. Adults with a history of eczema had lower odds of daily vigorous activity (aOR, 0.79; 95% CI, 0.63-0.99) and lower frequency of vigorous activity in the past week (adjusted beta, -0.46; 95% CI, -0.72 to -0.21) than did adults without a history of eczema. Those with eczema had a higher body mass index than did those without eczema (adjusted beta, 0.86; 95% CI, 0.37-1.36), particularly a body mass index of 35 or more (aOR, 1.54; 95% CI, 1.16-2.05), and higher odds of hypertension (aOR, 1.48; 95% CI, 1.18-1.85), hypertension on 2 visits (aOR, 1.56; 1.22-1.99), and lifetime prediabetes (aOR, 1.71; 95% CI, 1.19-2.45). Finally, there were significant interactions between eczema and sleep disturbances such that eczema associated with fatigue, daytime sleepiness, or insomnia was associated with even higher odds of obesity, hypertension, hypertension on 2 visits, prediabetes, diabetes, and high cholesterol than eczema alone.Conclusions: We found that eczema in adults is a marker for cardiovascular risk, emphasizing the importance of behavioral modification and perhaps more aggressive interventions to better manage eczema.