Reproductive Factors and Risk of Renal Cell Cancer
Reproductive Factors and Risk of Renal Cell Cancer
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DOI：
10.1093/aje/kwp030
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发表时间：
2009-05-15
影响因子：
5
通讯作者：
Cho, Eunyoung
中科院分区：
文献类型：
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作者：
Lee, Jung Eun;Hankinson, Susan E.;Cho, Eunyoung
很少有前瞻性研究研究生殖因素与肾细胞癌(RCC)风险的关系。在护士健康研究中，作者前瞻性地研究了118,219名美国妇女中绝经后激素(PMH)的使用、口服避孕药的使用、产次和其他生殖因素是否与肾癌风险有关。1976至2004年间共确诊247例肾细胞癌病例。经已知危险因素调整后的多变量相对危险度采用COX比例风险模型计算。与1胎或2胎相比，4胎和5胎的多因素相对危险度分别为1.75(95%CI：1.21，2.53)和1.50(95%CI：1.00，2.23)(P(趋势)=0.02)。比较初产年龄=28岁和初产年龄=26岁，多因素相对危险度为2.17(95%CI：1.49，3.14)，其中<gt；=4个孩子和初产年龄=26岁。未观察到PMH的使用或持续时间、自上次使用PMH以来的时间、口服避孕药的使用或持续时间、初潮年龄、绝经年龄、或子宫或卵巢切除术的病史。
Few prospective studies have examined associations between reproductive factors and risk of renal cell cancer (RCC). The authors prospectively examined whether postmenopausal hormone (PMH) use, oral contraceptive use, parity, and other reproductive factors were associated with RCC risk among 118,219 US women in the Nurses' Health Study. A total of 247 RCC cases were confirmed between 1976 and 2004. Multivariate relative risks, adjusted for known risk factors, were calculated using Cox proportional hazards models. Compared with 1 or 2 childbirths, the multivariate relative risks were 1.75 (95% confidence interval (CI): 1.21, 2.53) for 4 childbirths and 1.50 (95% CI: 1.00, 2.23) for >= 5 childbirths (P(trend) = 0.02). Comparing an age at first birth of >= 28 years with an age at first birth of = 26 years, the multivariate relative risk was 2.17 (95% CI: 1.49, 3.14) for >= 4 childbirths and an age at first birth of < 26 years. No clear associations were observed for PMH use or duration, time since last PMH use, oral contraceptive use or duration, age at menarche, age at menopause, or history of hysterectomy or oophorectomy.