Chiral Ferrocenyl P,N-Ligands for Palladium-Catalyzed Asymmetric Formal [3+2] Cycloaddition of Propargylic Esters with beta-Ketoesters: Access to Functionalized Chiral 2,3-Dihydrofurans
Chiral Ferrocenyl P,N-Ligands for Palladium-Catalyzed Asymmetric Formal [3+2] Cycloaddition of Propargylic Esters with beta-Ketoesters: Access to Functionalized Chiral 2,3-Dihydrofurans
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钯催化不对称缩甲醛的手性二茂铁基 P,N-配体 [3 2] 炔丙酯与 β-酮酯的环加成：获得功能化手性 2,3-二氢呋喃
DOI：
10.1021/acs.orglett.6b01192
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发表时间：
2016
期刊：
影响因子：
5.2
通讯作者：
Hu Xiang-Ping
中科院分区：
文献类型：
--
作者：
Zhou Yong;Zhu Fu-Lin;Liu Zhen-Ting;Zhou Xiao-Mao;Hu Xiang-Ping
A highly enantioselective palladium-catalyzed [3 + 2] cycloaddition of propargylic esters with β-ketoesters has been realized by employing a newly developed chiral ferrocene/benzimidazole-based P,N-ligand. This protocol features a good tolerance of functional groups in both propargylic esters and β-ketoesters, thereby delivering a variety of highly functionalized chiral 2,3-dihydrofurans bearing an exocyclic double bond at the 3-position in good yields and with high enantioselectivities (up to 98% ee).
