Prostaglandins A1, A2 and 19‐hydroxy A1; their actions on smooth muscle and their inactivation on passage through the pulmonary and hepatic portal vascular beds
Prostaglandins A1, A2 and 19‐hydroxy A1; their actions on smooth muscle and their inactivation on passage through the pulmonary and hepatic portal vascular beds
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前列腺素 A1、A2 和 19-羟基 A1 对平滑肌的作用及其在通过肺和肝门血管床时的失活；
DOI：
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发表时间：
1969
影响因子：
7.3
通讯作者：
J. Hopkin
中科院分区：
文献类型：
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作者：
E. Horton;R. L. Jones;J. Hopkin
1 .前列腺素A1、A2和19-羟基A1对平滑肌的作用在性质上与前列腺素E1相似。二、野牡丹素A对胃肠道、呼吸道和生殖平滑肌几乎没有活性，但对狗、猫和兔的全身动脉血压具有强效抑制作用。3 .第三章。我们的实验支持这样一种观点，即野牡丹素E和A的降压作用是由于对许多外周血管床的直接扩张作用，而不是由于这些血管床的神经张力的变化。四、单次通过猫或狗的肺循环导致前列腺素E1的血管扩张活性的显著损失，但几乎没有（如果有的话）前列腺素A的血管扩张活性的损失。五、通过猫的肝门静脉循环的单次通过导致了阿糖胞苷E1、A1和A2的血管扩张活性的实质性丧失。六、猫血压和大鼠胃底试纸条是一个合适的组合，用于平行生物测定的阿糖胞苷A1和A2。
1 . Prostaglandins A1, A2 and 19‐hydroxy A1 have qualitatively similar actions to prostaglandin E1 on smooth muscle. 2 . The prostaglandins A have little activity on gastrointestinal, respiratory and reproductive smooth muscle but are potent depressors of the systemic arterial blood pressure of the dog, cat and rabbit. 3 . Our experiments support the view that the depressor action of the prostaglandins E and A is due to a direct dilator action on many peripheral vascular beds and not due to changes in nervous tone to these beds. 4 . A single passage through the pulmonary circulation of the cat or dog causes substantial loss of the vasodilator activity of prostaglandin E1 but little if any loss of the vasodilator activity of the prostaglandins A. 5 . A single passage through the hepatic portal circulation of the cat causes substantial loss of the vasodilator activity of prostaglandins E1, A1 and A2. 6 . The cat blood pressure and rat fundal strip would be a suitable combination for the parallel biological assay of the prostaglandins A1 and A2.