Neurofibromatosis type 1: Diffusion weighted imaging findings of brain
Neurofibromatosis type 1: Diffusion weighted imaging findings of brain
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DOI：
10.1016/j.ejrad.2005.05.008
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发表时间：
2005-11-01
影响因子：
3.3
通讯作者：
Egri, M
中科院分区：
文献类型：
--
作者：
Alkan, A;Sigirci, A;Egri, M
目的：本研究旨在评估1型神经纤维瘤病（NF1）患者幕下和幕上不明原因高信号病灶（UBO）之间、UBO与正常表现侧（NAS，UBO对侧区域和/或无UBO的正常表现区域）之间表观扩散系数（ADC）值的差异，以及年龄与ADC值之间的相关性，并在对照组中进行同样评估。方法：共纳入30例患者和26名健康对照者。磁共振成像（MRI）检查包括常规成像和扩散加权成像（DWI）。选择七个不同部位（额叶、顶枕叶和小脑白质、苍白球、丘脑、海马体和中脑）进行分析。通过感兴趣区（ROI）直接从自动生成的ADC图计算ADC值。结果：与NAS和对照组相比，小脑白质、海马体、苍白球、中脑和丘脑的UBO的ADC值显著升高。从海马体和丘脑获得的ADC值在NAS组和对照组之间存在统计学显著差异。幕上和幕下UBO的ADC值之间存在统计学显著差异。年龄与从正常表现的中脑、海马体、丘脑和苍白球获得的ADC值之间呈负相关。结论：在NF1患者中，UBO以及海马体和丘脑等正常表现部位的ADC值均较高。在NF1中，病变的检测可能与MRI表现无关，即尽管大脑受到影响，但MRI表现可能正常。因此，在描绘NF1患者的脑部受累情况时，也应使用DWI和ADC值。（C）2005爱思唯尔爱尔兰有限公司。保留所有权利。
Purpose: The purposes of this study were to evaluate the differences in apparent diffusion coefficient (ADC) values between infra and supratentorial unidentified bright objects (UBOs), between UBOs and normal appearing side (NAS, contralateral regions of the UBOs and/or normal appearing region without UBOs) in the neurofibromatosis type 1 patients (NF1) and control group and also to investigate correlation between age and ADC values.Methods: A total of 30 patients and 26 healthy controls were included. The MRI examination consisted of routine imaging and diffusion weighted imaging (DWI). Seven distinct locations (frontal, parieto-occipital and cerebellar white matter, globus pallidum, thalamus, hippocampus, and midbrain) were selected for the analysis. The ADC values were calculated directly from these automatically generated ADC maps with ROI.Results: The ADC values of UBOs were significantly increased in cerebellar white matter, hippocampus, globus pallidum, midbrain, and thalamus when compared with NAS and control group. There were statistically significant differences between NAS and control group in the ADC values obtained from hippocampus and thalamus. There were statistically significant differences between supra and infratentorial UBOs in ADC values. There was a negative correlation between age and the ADC values obtained from normal appearing midbrain, hippocampus, thalamus, and globus pallidum.Conclusion: ADC values both in UBOs and in the normal appearing locations as hippocampus and thalamus were detected to be higher in the patients with NF1. The detection of lesions might be independent of MRI appearance in NF1, i.e. although the brain is affected, MRI appearance may be normal. Therefore, DWI and ADC values should also be utilized in the delineation of brain involvement of NF1 patients. (C) 2005 Elsevier Ireland Ltd. All rights reserved.