Complementary sequence preferences of electron-capture dissociation and vibrational excitation in fragmentation of polypeptide polycations
Complementary sequence preferences of electron-capture dissociation and vibrational excitation in fragmentation of polypeptide polycations
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DOI：
10.1002/anie.200601240
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发表时间：
2006-01-01
影响因子：
16.6
通讯作者：
Zubarev, Roman A.
中科院分区：
文献类型：
--
作者：
Savitski, Mikhail M.;Kjeldsen, Frank;Zubarev, Roman A.
互补裂解：在串联质谱中对裂解位点和碰撞激活解离（CAD）和电子捕获解离（ECD）的偏好进行了大规模（约15000光谱）比较，毫无疑问地证明了它们的互补性质（见图，红色：高，蓝色：低）。该研究还表明，在气相色氨酸指示中存在首选n端结构。
(Chemical Equation Presented) Complementary cleavage: A large-scale (ca. 15000 spectra) comparison between the cleavage sites and the preferences of collision-activated dissociation (CAD) and electron-capture dissociation (ECD) in tandem mass spectrometry has proved beyond doubt their complementary nature (see picture, red: high, blue: low). The study has also suggested the presence of a preferred N-terminal structure in gas-phase tryptic peptide dications.