Primate version of modified Rankin scale for classifying dysfunction in rhesus monkeys
Primate version of modified Rankin scale for classifying dysfunction in rhesus monkeys
复制标题
用于对恒河猴功能障碍进行分类的灵长类动物改良兰金量表
DOI：
10.1161/strokeaha.119.028108
复制
发表时间：
2020
期刊：
影响因子：
8.3
通讯作者：
Ji Xunming
中科院分区：
文献类型：
--
作者：
Wu Di;Wu Longfei;Chen Jian;Huber Mitchell;He Xiaoduo;Li Shengli;Ding Yuchuan;Ji Xunming
背景和目的非人灵长类动物越来越多地用于缺血性卒中的转化研究。然而，目前的评分系统在猴子（如，非人灵长类动物中风量表）不专注于日常生活活动的损害，因此临床相关的数据是稀缺的评估功能缺陷，在这个model.MethodsHere，我们参考了修改后的兰金量表，提供一个灵长类动物版本的兰金量表（pRS）在猴子中风后神经功能障碍的排名。我们选择手的功能和力量，活动水平，和一般的流动性作为pRS的主要组成部分。我们还分析了观察者间的变异性。ResultspRS是一个简单的规模只有6个水平。根据pRS，功能缺陷可以很容易地分为无（0类）、轻度（1-2类）、中度（3-4类）和重度残疾（5类）。我们在11只猴子身上验证了这个评分系统，所有猴子在中风后都有不同程度的神经功能障碍，由盲法测试者评估。经过短暂的培训期间，技术人员和神经病学居民都能够实现高水平的一致性，使用此评分system.ConclusionspRS是一个简单而可靠的功能量表，类似于广泛使用的修改后的兰金规模，用于评估长期的非人灵长类动物的神经功能障碍。我们建议进行进一步的验证研究和分析。
Background and PurposeNonhuman primates are increasingly used in translational studies of ischemic stroke. However, current scoring systems in monkeys (eg, Nonhuman Primate Stroke Scale) do not focus on impairments in activities of daily living, so clinically relevant data are scarce for evaluating functional deficits in this model.MethodsHere, we referenced the modified Rankin Scale to provide a primate version of Rankin Scale (pRS) for ranking neurological dysfunction in monkeys following stroke. We selected hand function and strength, level of activity, and general mobility as the main components of pRS. We also analyzed interobserver variability.ResultspRS is a simple scale with only 6 levels. Functional deficit can be easily classified into none (category 0), slight (categories 1–2), moderate (category 3–4), and severe disabilities (category 5) based on pRS. We validated this scoring system on 11 monkeys, all with varying levels of neurological dysfunction following stroke, assessed by blinded testers. After a short training period, both technicians and neurology residents were able to achieve a high level of consistency using this scoring system.ConclusionspRS is a simple and reliable functional scale, similar to the widely used modified Rankin Scale, for evaluating long-term neurological dysfunction in nonhuman primates. We recommend further validation studies and analyses.