Repair of Rat Calvarial Defects Using Si-Doped Hydroxyapatite Scaffolds Loaded With a Bone Morphogenetic Protein-2-Related Peptide
Repair of Rat Calvarial Defects Using Si-Doped Hydroxyapatite Scaffolds Loaded With a Bone Morphogenetic Protein-2-Related Peptide
复制标题
使用负载骨形态发生蛋白 2 相关肽的硅掺杂羟基磷灰石支架修复大鼠颅骨缺损。
DOI：
10.1002/jor.23208
复制
发表时间：
2016-11-01
影响因子：
2.8
通讯作者：
Guo, Xiaodong
中科院分区：
文献类型：
--
作者：
Cui, Wei;Sun, Guangfei;Guo, Xiaodong
组织工程有望成为治疗传统大骨损伤和缺损的理想疗法。在本研究中，我们开发了一种新型的Si-HA支架，装载了合成的BMP-2相关肽P28，并测试了其修复临界尺寸颅骨缺损的能力。我们在32只大鼠的顶骨中创建了一个颅骨缺损（直径5 mm），并植入以下生物材料之一：无植入物（对照）、Si-HA、P28/Si-HA或rhBMP-2/Si-HA。如通过显微CT成像和组织学评价所评估的，P28/Si-HA支架促进骨恢复的程度与rhBMP-2/Si-HA支架相似。此外，P28/Si-HA和rhBMP-2/Si-HA均比单独的Si-HA更好地促进恢复。新型P28/Si-HA支架可能代表未来骨组织工程应用的有前途的生物材料。(C)2016骨科研究学会。出版社：Wiley Periodicals，Inc.
Tissue engineering promises therapies ideal for treating conventional large bone injuries and defects. In the present study, we developed a novel Si-HA scaffold loaded with a synthetic BMP-2-related peptide, P28, and tested its ability to repair a critical-sized calvarial defect. We created a calvarial defect (5 mm in diameter) in the parietal bone of 32 rats and implanted one of the following biomaterials: No implant (control), Si-HA, P28/Si-HA, or rhBMP-2/Si-HA. As assessed by micro CT imaging and histological evaluations, the P28/Si-HA scaffold promoted bone recovery to a similar degree as the rhBMP-2/Si-HA scaffold. In addition, both P28/Si-HA and rhBMP-2/Si-HA promoted recovery better than Si-HA alone. The novel P28/Si-HA scaffold might represent a promising biomaterial for future bone tissue engineering applications. (C) 2016 Orthopaedic Research Society. Published by Wiley Periodicals, Inc.