The Angiomotins--from discovery to function.

The Angiomotins--from discovery to function.
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血管植物 - 从功能中发现。

DOI:
10.1016/j.febslet.2014.02.006
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发表时间:
2014-08-19
期刊:
影响因子:
3.5
通讯作者:
Kissil JL
Kissil JL
中科院分区:
生物学3区
文献类型:
--
作者:
Moleirinho S;Guerrant W;Kissil JL

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血管生成素最初被鉴定为血管生成抑制素结合蛋白,并参与内皮细胞迁移的调节。最近的研究揭示了血管生成素和运动蛋白家族的其他成员在上皮细胞中的作用,以及与癌症发病机制直接相关的途径。特别是,已显示Motins在由小G蛋白和Hippo-YAP途径调节的信号传导途径中发挥作用。在这篇综述中,将描述运动蛋白家族在这些信号通路中的作用,并讨论开放性问题。
Angiomotins were originally identified as angiostatin binding proteins and implicated in the regulation of endothelial cell migration. Recent studies have shed light on the role of Angiomotins and other members of the Motin protein family in epithelial cells and in pathways directly linked to the pathogenesis of cancer. In particular, Motins have been shown to play a role in signaling pathways regulated by small G-proteins and the Hippo-YAP pathway. In this review the role of the Motin protein family in these signaling pathways will be described and open questions will be discussed.
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