The brain-derived neurotrophic factor (BDNF) val66met polymorphism differentially affects performance on subscales of the Wechsler Memory Scale - Third Edition (WMS-III).
The brain-derived neurotrophic factor (BDNF) val66met polymorphism differentially affects performance on subscales of the Wechsler Memory Scale - Third Edition (WMS-III).
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脑衍生的神经营养因子（BDNF）Val66met多态性差异地影响了Wechsler记忆量表的子量表的性能 - 第三版（WMS-III）。
DOI：
10.3389/fpsyg.2015.01212
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发表时间：
2015
影响因子：
3.8
通讯作者：
Kirk IJ
中科院分区：
文献类型：
--
作者：
Lamb YN;Thompson CS;McKay NS;Waldie KE;Kirk IJ
脑源性神经营养因子（BDNF）基因和儿茶酚-O-甲基转移酶（COMT）基因的单核苷酸多态性影响大脑结构和功能以及认知能力。它们分别在海马体和前额叶皮层（PFC）中最有影响力。回忆和识别是记忆的形式，被认为具有不同的神经基质，回忆更依赖于PFC和海马体。本研究旨在确定BDNF val 66 met或COMT val 158 met多态性是否差异影响回忆和识别，以及这些多态性是否相互作用。使用韦氏记忆量表第三版（WMS-III）的面孔和家庭图片子量表，对100名健康成年人的回忆和基于熟悉度的识别进行了评估。COMT基因型并不影响这两项任务的表现。BDNF多态性（即，MET携带者相对于瓦尔纯合子）与较差的回忆能力相关，但不影响识别。结合记忆测试（如WMS）中的子量表分数可能会掩盖基因效应。我们的研究结果证明了在神经遗传学研究中区分回忆和熟悉性识别的重要性。
Single nucleotide polymorphisms in the brain-derived neurotrophic factor (BDNF) gene and the catechol-O-methyltransferase (COMT) gene influence brain structure and function, as well as cognitive abilities. They are most influential in the hippocampus and prefrontal cortex (PFC), respectively. Recall and recognition are forms of memory proposed to have different neural substrates, with recall having a greater dependence on the PFC and hippocampus. This study aimed to determine whether the BDNF val66met or COMT val158met polymorphisms differentially affect recall and recognition, and whether these polymorphisms interact. A sample of 100 healthy adults was assessed on recall and familiarity-based recognition using the Faces and Family Pictures subscales of the Wechsler Memory Scale – Third Edition (WMS-III). COMT genotype did not affect performance on either task. The BDNF polymorphism (i.e., met carriers relative to val homozygotes) was associated with poorer recall ability, while not influencing recognition. Combining subscale scores in memory tests such as the WMS might obscure gene effects. Our results demonstrate the importance of distinguishing between recall and familiarity-based recognition in neurogenetics research.