Bilayered nail lacquer of terbinafine hydrochloride for treatment of onychomycosis.
Bilayered nail lacquer of terbinafine hydrochloride for treatment of onychomycosis.
复制标题
盐酸特比萘芬双层指甲油治疗甲癣。
DOI：
10.1002/jps.22150
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发表时间：
2010
影响因子：
3.8
通讯作者：
Murthy,SNarasimha
中科院分区：
文献类型：
--
作者：
Shivakumar,HN;Vaka,SivaRamKiran;Madhav,NVSatheesh;Chandra,Harish;Murthy,SNarasimha
The present study aimed to develop bilayered nail lacquer of terbinafine hydrochloride (TH) for treatment of onychomycosis. The composite nail lacquer formed an underlying drug-loaded hydrophilic layer and overlying hydrophobic vinyl layer. The hydrophilic lacquer made of hydroxylpropyl methylcellulose E-15 contained polyethylene glycol 400 (PEG 400) as a drug permeation enhancer. The vinyl lacquer was composed of poly (4-vinyl phenol) as a water- resistant film former.In vitropermeation studies in Franz diffusion cells indicated that the amount of TH permeated across the human cadaver nail in 6 days was 0.32 ± 0.14, 1.12 ± 0.42, and 1.42 ± 0.53 μg/cm2from control (hydrophilic lacquer devoid of PEG 400), monolayer (hydrophilic lacquer alone), and bilayered nail lacquers, respectively. A higher nail drug load was seenin vitrowith the bilayered lacquer (0.59 ± 0.13 μg/mg) as compared to monolayer (0.36 ± 0.09 μg/ mg) and control (0.28 ± 0.07 μg/mg) lacquers. The drug loss despite multiple washing was significantly low (p< 0.001) for the bilayered lacquer owing to the protective vinyl coating. Clinical studies demonstrated the efficacy of bilayered lacquer to achieve better drug load in the nail plate (1.27 ± 0.184 μg/mg) compared to monolayer (0.67 ± 0.18 μg/mg) and control (0.21 ± 0.04 μg/mg) lacquers.
