Protein-Carbon Dot Nanohybrids Based Early Blood Brain Barrier Damage Theranostics. ACS Applied Materials & Interfaces
Protein-Carbon Dot Nanohybrids Based Early Blood Brain Barrier Damage Theranostics. ACS Applied Materials & Interfaces
复制标题
基于蛋白-碳点纳米混合体的早期血脑屏障损伤治疗诊断学
DOI：
10.1021/acsami.9b19378
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发表时间：
2020
影响因子：
9.5
通讯作者：
Xiaozhong Qu
中科院分区：
文献类型：
--
作者：
Yuefang Niu;Hui Tan;Xiaofeng Li;Lingling Zhao;Zheng Xie;Yuan Zhang;Shuyun Zhou;Xiaozhong Qu
For effective treatment of ischemic cerebral thrombosis, it is of great significance to find a facile way in assessing the early damage of blood–brain barrier (BBB) after ischemic stroke during thrombolysis by integrating thrombolytic agents with fluorescent materials. Herein, a novel type of protein–carbon dot nanohybrids is reported by the incorporation of carbon dots on thrombolytic agents through covalent linkage. Both in vitro and ex vivo fluorescence imaging measurements have demonstrated remarkable imaging effects in the brain of transient middle cerebral artery occlusion mice. Besides, the outstanding thrombolytic capacity of the nanohybrids was determined by in vitro thrombolysis tests. As one of the few reports of the construction of thrombolytic agents and fluorescent nanomaterials, the nanohybrids retain thrombolysis ability and fluorescent traceability simultaneously. It may provide a promising indicator for early BBB damage and thrombolytic agent distribution to estimate the possibility of symptomatic intracranial hemorrhage after thrombolysis and supply tissue window evidence for clinical thrombolytic agent application.
