Immunotherapy for Breast Cancer: Current and Future Strategies
Immunotherapy for Breast Cancer: Current and Future Strategies
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DOI：
10.1007/s40137-017-0194-1
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发表时间：
2017-12-01
影响因子：
0.6
通讯作者：
Tchou, Julia
中科院分区：
文献类型：
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作者：
Williams, Austin D.;Payne, Kyle K.;Tchou, Julia
研究目的乳腺肿瘤微环境具有免疫抑制作用，在肿瘤发生中起着重要作用。对恶性肿瘤和免疫细胞之间正常和异常相互作用的深入了解，使研究人员能够利用新的免疫治疗策略来利用免疫系统，其中许多策略在乳腺癌中显示出了希望。本文就免疫疗法在乳腺癌治疗中的应用作一综述。近年来，免疫疗法在乳腺癌治疗中的应用无论是基础科学还是临床试验数据都在迅速发展。目前的临床试验包括治疗性疫苗、免疫检查点阻断、抗体、细胞因子和过继细胞治疗。摘要尽管早期失败，但免疫治疗策略在乳腺癌治疗中的应用前景光明。
Purpose of Review The breast tumor microenvironment is immunosuppressive and is increasingly recognized to play a significant role in tumorigenesis. A deeper understanding of normal and aberrant interactions between malignant and immune cells has allowed researchers to harness the immune system with novel immunotherapy strategies, many of which have shown promise in breast cancer. This review discusses the application of immunotherapy to the treatment of breast cancer.Recent Findings Both basic science and clinical trial data are rapidly developing in the use of immunotherapy for breast cancer. The current clinical trial landscape includes therapeutic vaccines, immune checkpoint blockade, antibodies, cytokines, and adoptive cell therapy.Summary Despite early failures, the application of immunotherapeutic strategies to the treatment of breast cancer holds promise.