Disease burden of the most commonly detected respiratory viruses in hospitalized patients calculated using the disability adjusted life year (DALY) model
Disease burden of the most commonly detected respiratory viruses in hospitalized patients calculated using the disability adjusted life year (DALY) model
复制标题
DOI：
10.1016/j.jcv.2011.07.017
复制
发表时间：
2011-11-01
影响因子：
8.8
通讯作者：
Simmonds, P.
中科院分区：
文献类型：
--
作者：
Gaunt, E. R.;Harvala, H.;Simmonds, P.
背景：最常见的急性感染发生在呼吸道。最近发现的几种新的病毒已显着增加了解到引起急性呼吸道diseases.Objectives介绍的代理剧目：需要进一步了解的相对重要性，新发现的病原体在临床上设置提供临床医生与适当的诊断和治疗目标的指示。为了解决这一问题，呼吸道病毒在住院患者的疾病负担进行了量化。研究设计：呼吸道病毒在住院患者引起的疾病负担进行了量化使用世界卫生组织认可的DALY模型。将三年内采集的腺病毒（AdV）、流感A和B、副流感病毒1、2和3（PIV-1、-2和-3）、呼吸道合胞病毒（HRSV）样本的诊断检测结果以及先前发表的人偏肺病毒、鼻病毒和四种呼吸道冠状病毒的回顾性筛查结果应用于DALY模型。残疾的重量计算每1000名住院患者的年龄段groups.Results：观察儿童和成人的疾病负担显着不同的配置文件。腺病毒是儿童呼吸道疾病的主要原因之一，但不是成人。无论抽样人群如何，HRSV和甲型流感始终是疾病的最大病因之一。鼻病毒和PIV-3是除16-64岁年龄组外所有组的重要病原体。在免疫功能低下的患者鼻病毒的主要病毒病因diseases.Conclusions：这些分析提供了一个框架，可用于确定有限的资源，应针对呼吸道治疗和疫苗开发。(C)2011年爱思唯尔B。V.保留所有权利。
Background: The most common acute infections occur in the respiratory tract. Recent discoveries of several novel viruses have markedly increased the repertoire of agents understood to cause presentations of acute respiratory disease.Objectives: Further understanding is needed of the relative importance of newly discovered pathogens in the clinical setting to provide clinicians with an indication of appropriate diagnostic and therapeutic targets. To address this, quantification of the disease burden of respiratory viruses in hospitalized patients was undertaken.Study design: Disease burden caused by respiratory viruses in hospitalized patients was quantified using the World Health Organization endorsed DALY model. Diagnostic testing results from samples collected over three years for adenovirus (AdV), influenzas A and B, parainfluenza viruses 1, 2 and 3 (PIV-1, -2 and -3), respiratory syncytial virus (HRSV), and previously published retrospective screening for human metapneumovirus, rhinoviruses, and four respiratory coronaviruses were applied to the DALY model. Disability weights were calculated per 1000 hospitalized patients in age banded groups.Results: Strikingly different disease burden profiles were observed in children and adults. Adenoviruses were among the leading cause of respiratory presentations in children but not adults. HRSV and influenza A were consistently one of the greatest causes of disease regardless of sampled population. Rhinoviruses and PIV-3 were significant pathogens in all groups except those aged 16-64 years. In immunocompromised patients rhinoviruses were the leading viral cause of disease.Conclusions: These analyses provide a framework which can be used to identify where finite resources should be directed in respiratory therapeutics and vaccine development. (C) 2011 Elsevier B. V. All rights reserved.