YEATS domain proteins: a diverse family with many links to chromatin modification and transcription
YEATS domain proteins: a diverse family with many links to chromatin modification and transcription
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DOI：
10.1139/o08-111
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发表时间：
2009-02-01
影响因子：
2.9
通讯作者：
Kobor, Michael S.
中科院分区：
文献类型：
--
作者：
Schulze, Julia M.;Wang, Alice Y.;Kobor, Michael S.
染色质修饰在各种生物过程中起着至关重要的作用，越来越多的保守蛋白结构域，通常在多亚基蛋白复合物中发现，参与建立和识别不同的染色质修饰。YEATS结构域是这些结构域之一，它在染色质修饰和转录中的作用才刚刚开始被认识到。YEATS结构域蛋白家族，从酵母到人类，在70多种真核生物中包含100多个成员。Yaf9， Taf14和Sas5是酿酒酵母中仅有的YEATS结构域蛋白。人类YEATS结构域家族成员，如GAS41、ENL和AF9，与癌症有很强的联系。GAS41在胶质母细胞瘤和星形细胞瘤中扩增；ENL和AF9是混合谱系白血病（MLL）基因中最常见的易位伴侣。本文将重点介绍最具特征的YEATS蛋白，讨论它们的不同作用，并反映YEATS结构域的潜在功能。
Chromatin modifications play crucial roles in various biological processes, An increasing number of conserved protein domains, often found in multisubunit protein complexes, are involved in establishing and recognizing different chromatin modifications. The YEATS domain is one of these domains, and its role in chromatin modifications and transcription is just beginning to be appreciated. The YEATS domain family of proteins, conserved from yeast to human, contains over 100 members in more than 70 eukaryotic species. Yaf9, Taf14, and Sas5 Lire the only YEATS domain proteins in Saccharomyces cerevisiae. Human YEATS domain family members, such as GAS41, ENL, and AF9, have a strong link to cancer. GAS41 is amplified in glioblastomas and astrocytoma; ENL and AF9 are among the most frequent translocation partners of the mixed lineage leukemia (MLL) gene. This review will focus on the best characterized YEATS proteins, discuss their diverse roles, and reflect potential functions of the YEATS domain.