Prevalence and correlates of sleep-disordered breathing in older men: Osteoporotic fractures in men sleep study
Prevalence and correlates of sleep-disordered breathing in older men: Osteoporotic fractures in men sleep study
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DOI：
10.1111/j.1532-5415.2007.01290.x
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发表时间：
2007-09-01
影响因子：
6.3
通讯作者：
Redline, Susan
中科院分区：
文献类型：
--
作者：
Mehra, Reena;Stone, Katie L.;Redline, Susan
目的：使用多种标准化定义确定一大群老年男性中睡眠呼吸障碍的患病率和分布以及相关因素。设计：横断面分析。地点：美国六个社区。参与者：对老年男性睡眠障碍结果研究的 2,911 名参与者进行多导睡眠图检查（平均年龄 +/- 标准差 76.38 +/- 5.53；体重指数27.17 +/- 3.8 kg/m(2))。测量：评估了三种结果：睡眠呼吸障碍（呼吸障碍指数 >= 15）、阻塞性呼吸暂停（阻塞性呼吸暂停指数 >= 5）和中枢性呼吸暂停（中枢性呼吸暂停指数 >= 5）。结果：中重度睡眠呼吸障碍的患病率估计为 21.4%至 26.4%。多变量逻辑回归模型表明，年龄（调整后比值比 (AOR) 每 5 年增加 =1.24，95% 置信区间 (CI)=1.15-1.34）、肥胖（AOR=2.54，95% CI=2.09-3.09）、亚洲人种与白人种族（AOR=2.14，95% CI=1.33-3.45）、打鼾（AOR=2.01，95% CI=1.62-2.49）、嗜睡（AOR=1.41，95% CI=1.11-1.79）、高血压（AOR=1.26，95% CI=1.06-1.50）、心血管疾病（AOR=1.24，95% CI=1.19-1.29）和心力衰竭(AOR=1.81, 1.31-2.51) 与睡眠呼吸障碍独立相关；打鼾（AOR=2.10，95% CI=1.67-2.70）、年龄（每 5 年增加 AOR=1.27，95% CI=1.18-1.38）、肥胖（AOR=1.48，95% CI=1.21-1.82）和心力衰竭（AOR=1.60，95% CI=1.15-2.24）与阻塞性呼吸暂停有关；年龄 (AOR=1.33, 1.17-1.50) 和心力衰竭 (AOR=1.88, 95% CI=1.17-3.04) 与中枢性呼吸暂停相关。结论：无论定义如何，社区老年男性中睡眠障碍的患病率很高。据报道，中年人群的睡眠障碍与打鼾、肥胖和合并症之间存在定性相似的关联。亚洲人种与睡眠呼吸障碍有关。
OBJECTIVES: To determine the prevalence and distribution of sleep-disordered breathing and associated correlates in a large cohort of older men using several standardized definitions.DESIGN: Cross-sectional analyses.SETTING: Six U.S. communities.PARTICIPANTS: Polysomnography was performed on 2,911 participants of the Outcomes of Sleep Disorders in Older Men Sleep Study (mean age +/- standard deviation 76.38 +/- 5.53; body mass index 27.17 +/- 3.8 kg/m(2)).MEASUREMENTS: Three outcomes were assessed: sleep-disordered breathing (respiratory disturbance index >= 15), obstructive apnea (obstructive apnea index >= 5), and central apnea (central apnea index >= 5).RESULTS: The prevalence of moderate-severe sleep-disordered breathing was estimated to be 21.4% to 26.4%. Multivariable logistic regression models demonstrated that age (adjusted odds ratio (AOR) per 5-year increase =1.24, 95% confidence interval (CI)=1.15-1.34), obesity (AOR=2.54, 95% CI=2.09-3.09), Asian versus Caucasian race (AOR=2.14, 95% CI=1.33-3.45), snoring (AOR=2.01, 95% CI=1.62-2.49), sleepiness (AOR=1.41, 95% CI=1.11-1.79), hypertension (AOR=1.26, 95% CI=1.06-1.50), cardiovascular disease (AOR=1.24, 95% CI=1.19-1.29), and heart failure (AOR=1.81, 1.31-2.51) were independently associated with sleep-disordered breathing; snoring (AOR=2.10, 95% CI=1.67-2.70), age (AOR per 5-year increase=1.27, 95% CI=1.18-1.38), obesity (AOR=1.48, 95% CI=1.21-1.82), and heart failure (AOR=1.60, 95% CI=1.15-2.24) were associated with obstructive apnea; and age (AOR=1.33, 1.17-1.50) and heart failure (AOR=1.88, 95% CI=1.17-3.04) were associated with central apnea.CONCLUSION: Regardless of definition, a high prevalence of sleep disorders is observed in community-dwelling older men. Qualitatively similar associations were observed between sleep disorders and snoring, obesity, and comorbidities, as reported for middle aged populations. Asian race was associated with sleep-disordered breathing.