Correlation between metabolic tumor volume and pathologic tumor volume in squamous cell carcinoma of the oral cavity
Correlation between metabolic tumor volume and pathologic tumor volume in squamous cell carcinoma of the oral cavity
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DOI：
10.1016/j.radonc.2011.05.040
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发表时间：
2011-12-01
影响因子：
5.7
通讯作者：
Le, Quynh-Thu
中科院分区：
文献类型：
--
作者：
Murphy, James D.;Chisholm, Karen M.;Le, Quynh-Thu
目的：探讨口腔癌18F-脱氧葡萄糖(FDG)正电子发射断层扫描(PET)不同肿瘤分割技术所估算的肿瘤体积与病理肿瘤体积的关系。材料与方法：23例口腔鳞癌患者在手术前均行PET-CT扫描。病理肿瘤体积由手术标本估计。代谢肿瘤体积(MTV)由PET-CT扫描定义为肿瘤体积超过给定的SUV阈值。结果：多个MTV与病理肿瘤体积相关，但相关性较差(R(2)为0.29~0.58)。理想的SUV阈值定义为产生与病理肿瘤体积相等的MTV的SUV，与最大SUV(p=0.0005)和肿瘤分级(p=0.024)独立相关。MTV定义为最大SUV和肿瘤分级的函数，改善了对病理肿瘤体积的预测(R(2)=0.63)。结论：常见的SUV阈值不能预测头颈部肿瘤的病理体积。使PET-CT与放射治疗计划相结合的最佳技术仍有待确定。未来的研究应将肿瘤分级等生物标记物纳入MTV的定义。(C)2011爱思唯尔爱尔兰有限公司。保留所有权利。放射治疗与肿瘤学101(2011)356-361
Purpose: To explore the relationship between pathologic tumor volume and volume estimated from different tumor segmentation techniques on (18)F-fluorodeoxyglucose (FDG) positron emission tomography (PET) in oral cavity cancer.Materials and methods: Twenty-three patients with squamous cell carcinoma of the oral tongue had PET-CT scans before definitive surgery. Pathologic tumor volume was estimated from surgical specimens. Metabolic tumor volume (MTV) was defined from PET-CT scans as the volume of tumor above a given SUV threshold. Multiple SUV thresholds were explored including absolute SUV thresholds, relative SUV thresholds, and gradient-based techniques.Results: Multiple MTV's were associated with pathologic tumor volume; however the correlation was poor (R(2) range 0.29-0.58). The ideal SUV threshold, defined as the SUV that generates an MTV equal to pathologic tumor volume, was independently associated with maximum SUV (p = 0.0005) and tumor grade (p = 0.024). MTV defined as a function of maximum SUV and tumor grade improved the prediction of pathologic tumor volume (R(2) = 0.63).Conclusions: Common SUV thresholds fail to predict pathologic tumor volume in head and neck cancer. The optimal technique that allows for integration of PET-CT with radiation treatment planning remains to be defined. Future investigation should incorporate biomarkers such as tumor grade into definitions of MTV. (C) 2011 Elsevier Ireland Ltd. All rights reserved. Radiotherapy and Oncology 101 (2011) 356-361