Neural stem cells in mammalian development
Neural stem cells in mammalian development
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DOI：
10.1016/j.ceb.2006.09.008
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发表时间：
2006-12-01
影响因子：
7.5
通讯作者：
Alvarez-Buylla, Arturo
中科院分区：
文献类型：
--
作者：
Merkle, Florian T.;Alvarez-Buylla, Arturo
神经干细胞（NSCs）是在胚胎、新生儿和成年大脑中产生神经元和神经胶质细胞的主要祖细胞。近年来，我们对这些细胞有了三个重要的了解。首先，神经干细胞对应于先前被认为是定向神经胶质细胞的细胞。其次，胚胎神经干细胞和成年神经干细胞有谱系关联：它们从神经上皮细胞转变为放射状胶质细胞，然后转变为具有星形胶质细胞特征的细胞。第三，神经干细胞不对称分裂，并经常通过对称分裂的中间祖细胞增加它们所产生的后代数量。这些进展挑战了我们对神经胶质细胞和干细胞的传统认知，并为理解哺乳动物神经干细胞行为的分子基础提供了依据。
Neural stem cells (NSCs) are primary progenitors that give rise to neurons and glia in the embryonic, neonatal and adult brain. In recent years, we have learned three important things about these cells. First, NSCs correspond to cells previously thought to be committed glial cells. Second, embryonic and adult NSCs are lineally related: they transform from neuroepithelial cells into radial glia, then into cells with astroglial characteristics. Third, NSCs divide asymmetrically and often amplify the number of progeny they generate via symmetrically dividing intermediate progenitors. These advances challenge our traditional perceptions of glia and stem cells, and provide the foundation for understanding the molecular basis of mammalian NSC behavior.