Cortical contributions to the auditory frequency-following response revealed by MEG.
Cortical contributions to the auditory frequency-following response revealed by MEG.
复制标题
MEG揭示的对听觉频率遵循响应的皮质贡献。
DOI：
10.1038/ncomms11070
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发表时间：
2016-03-24
影响因子：
16.6
通讯作者：
Zatorre RJ
中科院分区：
文献类型：
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作者：
Coffey EB;Herholz SC;Chepesiuk AM;Baillet S;Zatorre RJ
对复杂周期性声音的听觉频率跟随反应（FFR）用于研究皮层下听觉系统，并已被提议作为以异常声音处理为特征的疾病的生物标志物。尽管其在基础和临床研究中具有价值，但血流储备分数的神经起源尚不清楚。使用脑磁图，除了来自耳蜗核、下丘和内侧膝状体的信号之外，我们还观察到在刺激的基频下来自人类听觉皮层的对FFR的强的、右不对称的贡献。这一发现与我们对听觉系统的可塑性和病理学的理解以及更高层次的认知（如语音和音乐处理）高度相关。这表明先前对FFR的解释可能需要使用允许源分离的方法进行重新检查。 听觉脑干反应（ABR）是用来研究音乐和语言中听觉信息的时间编码。本研究利用脑磁图定位皮质和皮质下起源的持续频率以下的反应（FFR），ABR组件编码的周期性的声音。
The auditory frequency-following response (FFR) to complex periodic sounds is used to study the subcortical auditory system, and has been proposed as a biomarker for disorders that feature abnormal sound processing. Despite its value in fundamental and clinical research, the neural origins of the FFR are unclear. Using magnetoencephalography, we observe a strong, right-asymmetric contribution to the FFR from the human auditory cortex at the fundamental frequency of the stimulus, in addition to signal from cochlear nucleus, inferior colliculus and medial geniculate. This finding is highly relevant for our understanding of plasticity and pathology in the auditory system, as well as higher-level cognition such as speech and music processing. It suggests that previous interpretations of the FFR may need re-examination using methods that allow for source separation. Auditory brainstem response (ABR) is used to study temporal encoding of auditory information in music and language. This study utilizes magnetoencephalography to localize both cortical and subcortical origins of the sustained frequency following response (FFR), the ABR component that encodes the periodicity of sound.