YAP promotes the activation of NLRP3 inflammasome via blocking K27-linked polyubiquitination of NLRP3.
YAP promotes the activation of NLRP3 inflammasome via blocking K27-linked polyubiquitination of NLRP3.
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YAP 通过阻断 NLRP3 K27 连接的多聚泛素化促进 NLRP3 炎症小体的激活
DOI：
10.1038/s41467-021-22987-3
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发表时间：
2021-05-11
影响因子：
16.6
通讯作者：
Zhao K
中科院分区：
文献类型：
--
作者：
Wang D;Zhang Y;Xu X;Wu J;Peng Y;Li J;Luo R;Huang L;Liu L;Yu S;Zhang N;Lu B;Zhao K
The transcription coactivator YAP plays a vital role in Hippo pathway for organ-size control and tissue homeostasis. Recent studies have demonstrated YAP is closely related to immune disorders and inflammatory diseases, but the underlying mechanisms remain less defined. Here, we find that YAP promotes the activation of NLRP3 inflammasome, an intracellular multi-protein complex that orchestrates host immune responses to infections or sterile injuries. YAP deficiency in myeloid cells significantly attenuates LPS-induced systemic inflammation and monosodium urate (MSU) crystals-induced peritonitis. Mechanistically, YAP physically interacts with NLRP3 and maintains the stability of NLRP3 through blocking the association between NLRP3 and the E3 ligase β-TrCP1, the latter increases the proteasomal degradation of NLRP3 via K27-linked ubiquitination at lys380. Together, these findings establish a role of YAP in the activation of NLRP3 inflammasome, and provide potential therapeutic target to treat the NLRP3 inflammasome-related diseases.
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影响因子：
29.7
作者：
Davis BK;Wen H;Ting JP
通讯作者：
Ting JP
影响因子：
10.5
作者：
Chen Q;Zhang N;Xie R;Wang W;Cai J;Choi KS;David KK;Huang B;Yabuta N;Nojima H;Anders RA;Pan D
通讯作者：
Pan D
影响因子：
20.1
作者：
Lv Y;Kim K;Sheng Y;Cho J;Qian Z;Zhao YY;Hu G;Pan D;Malik AB;Hu G
通讯作者：
Hu G
白介素-1和炎性体作为心血管疾病的治疗靶标。
影响因子：
20.1
作者：
Abbate A;Toldo S;Marchetti C;Kron J;Van Tassell BW;Dinarello CA
通讯作者：
Dinarello CA
影响因子：
16.6
作者：
Phan L;Chou PC;Velazquez-Torres G;Samudio I;Parreno K;Huang Y;Tseng C;Vu T;Gully C;Su CH;Wang E;Chen J;Choi HH;Fuentes-Mattei E;Shin JH;Shiang C;Grabiner B;Blonska M;Skerl S;Shao Y;Cody D;Delacerda J;Kingsley C;Webb D;Carlock C;Zhou Z;Hsieh YC;Lee J;Elliott A;Ramirez M;Bankson J;Hazle J;Wang Y;Li L;Weng S;Rizk N;Wen YY;Lin X;Wang H;Wang H;Zhang A;Xia X;Wu Y;Habra M;Yang W;Pusztai L;Yeung SC;Lee MH
通讯作者：
Lee MH