Engineering strategies to emulate the stem cell niche.
Engineering strategies to emulate the stem cell niche.
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DOI：
10.1016/j.tibtech.2009.11.008
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发表时间：
2010-03
影响因子：
17.3
通讯作者：
T. Vazin;D. Schaffer
中科院分区：
文献类型：
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作者：
T. Vazin;D. Schaffer
干细胞生态位是一个解剖部位，其中包含多能干细胞（SC）库，可以维持正常组织，或补充受损或老化的细胞群，以响应调节它们是否应保持静止、进行自我更新或分化的机制。这些标志性 SC 行为之间的选择受到系统性或由局部利基细胞呈现的复杂可溶性和“固相”信号的控制。在这篇综述中，我们讨论了在理解 SC 行为的微环境调节机制和原理方面取得的进展，并重点关注已开发的用于合成这些基本信息的新方法，以设计利用和控制 SCsex 体内和体内的创造性策略。
The stem cell niche is an anatomical site that contains a reservoir of multipotent stem cells (SCs) that can maintain normal tissue, or replenish injured or aged cell populations, in response to mechanisms that regulate whether they should remain quiescent, undergo self-renewal, or differentiate. The choice among these hallmark SC behaviors is governed by intricate soluble and "solid phase" signals that are systemic or presented by the local niche cells. In this review, we discuss the progress achieved in understanding the mechanisms and principles that govern microenvironmental regulation of SC behavior, and focus on novel approaches that have been developed to synthesize this basic information to engineer creative strategies for harnessing and controlling SCsex vivoandin vivo.