Poisoning severity score.: Grading of acute poisoning
Poisoning severity score.: Grading of acute poisoning
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DOI：
10.3109/15563659809028940
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发表时间：
1998-01-01
期刊：
影响因子：
--
通讯作者：
de Garbino, JP
中科院分区：
文献类型：
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作者：
Persson, HE;Sjöberg, GK;de Garbino, JP
背景资料：中毒严重程度分级的标准化和普遍适用的方案可以对发病率进行定性评价，并有助于数据的可比性。根据欧洲毒物中心和临床毒理学家协会提出的一个简单分级表，与国际化学品安全方案和欧洲联盟委员会联合制定了中毒严重程度评分。方法：在1991-1994年的一个项目中，对中毒严重程度评分进行了详细阐述、测试和逐步修订。来自不同国家的14个毒物中心参加了会议。每个中心对371例由10种不同毒剂引起的急性中毒病例进行独立分级。然后对数据进行分析和比较。结果如下：在研究期间，严重程度分级的一致性增加，在最后一个阶段，80%或更多病例的中心间一致性可接受。考虑到原始病例记录的条件和质量，认为该结果令人满意，并就此处提出的评分方案达成一致。中毒严重程度评分将严重程度分级为（0）无，（1）轻微，（2）中度，（3）重度和（4）致命中毒。其旨在对病例进行总体评价，同时考虑到最严重的临床特征。中毒严重程度评分的使用通常需要对所有病例进行随访，但如果在提供数据时明确说明，则可以在入院时或中毒过程中的其他时间使用。结论：中毒严重程度评分已被开发，并发现适用于中毒的严重程度分级。可以预见，中毒严重程度评分将达到预期，并在实践中使用，但其未来的使用和评估可能会导致一些进一步的修订和完善。
Background: A standardized and generally applicable scheme for grading the severity of poisoning allows a qualitative evaluation of morbidity and facilitates comparability of data. Working from a simple grading scale proposed by the European Association of Poisons Centres and Clinical Toxicologists, a Poisoning Severity Score has been developed jointly with the International Programme on Chemical Safety and the European Commission. Methods: The Poisoning Severity Score has been elaborated, tested, and gradually revised during a project running 1991-1994. Fourteen poisons centers from various countries have participated. Each center independently graded 371 cases of acute poisoning by ten different toxic agents. The data were then analyzed and compared. Results: The concordance in grading the severity increased during the study period, and in the last phase there was an acceptable concordance among centers in 80% or more of the cases. Given the condition and quality of the original case records, this result was considered satisfactory and agreement was reached on the scoring scheme presented here. The Poisoning Severity Score grades severity as (0) none, (1) minor, (2) moderate, (3) severe, and (4) fatal poisoning. It is intended to be an overall evaluation of the case, taking into account the most severe clinical features. Use of the Poisoning Severity Score normally requires a follow-up of all cases, but may be used on admission or other times during the course of poisoning if this is dearly stated when data are presented. Conclusions: A Poisoning Severity Score has been developed and found applicable for grading the severity of poisoning. It is foreseen that the Poisoning Severity Score will meet the expectations and be used in practice, but its future use and evaluation may result in some further revision and refinement.