Molecular organization, trafficking, and degradation of the GABA-B receptor
Molecular organization, trafficking, and degradation of the GABA-B receptor
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GABA-B 受体的分子组织、运输和降解
DOI：
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发表时间：
2016
期刊：
影响因子：
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通讯作者：
Khaled Zemoura
中科院分区：
文献类型：
--
作者：
D. Benke;Karthik Balakrishnan;Khaled Zemoura
GABAB受体是由两个跨膜蛋白GABAB1和GABAB2组成的异二聚体G蛋白偶联受体。它们在绝大多数神经元中表达，主要通过几个不同的效应系统调节神经元的兴奋性。有证据表明，GABAB受体被组织成由辅助蛋白和效应蛋白组成的大分子复合体，以确保有效的信号转导。通过GABAB受体的通讯和调节是由不断增加的相互作用蛋白决定的。特别是，调节受体细胞表面可用性从而调节其信号强度的运输事件受蛋白质-蛋白质相互作用控制，蛋白质相互作用通常传递翻译后修饰，如磷酸化或泛素化。了解GABAB受体可用性的调节机制非常重要，因为越来越多的人认识到GABAB受体细胞表面表达的异常调节与成瘾、脑缺血和慢性疼痛等疾病状态有关。在这里，我们简要回顾了我们目前对GABAB受体复合体的大分子结构组织以及通过转运事件和受控的受体降解来调节细胞表面受体可用性的理解。
GABAB receptors are heterodimeric G protein-coupled receptors composed of the two seven transmembrane spanning proteins GABAB1 and GABAB2. They are expressed in the vast majority of neurons and primarily regulate neuronal excitability via several distinct effector systems. There is evidence that GABAB receptors are organized in large macromolecular complexes composed of accessory and effector proteins to ensure efficient signaling. Communication through and regulation of GABAB receptors is determined by a constantly growing list of interacting proteins. In particular, trafficking events that regulate the cell surface availability of the receptors and thereby their signaling strength are controlled by protein–protein interactions that often convey posttranslational modifications such as phosphorylation or ubiquitination. Understanding the mechanisms regulating GABAB receptor availability is of major importance since it is increasingly recognized that aberrant regulation of GABAB receptor cell surface expression contributes to disease states including addiction, cerebral ischemia, and chronic pain. Here we briefly review our current understanding of the macromolecular structural organization of GABAB receptor complexes and the regulation of cell surface receptor availability by trafficking events and controlled receptor degradation.
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影响因子：
11
作者：
Workman, E. R.;Haddick, P. C. G.;Bush, K.;Dilly, G. A.;Niere, F.;Zemelman, B. V.;Raab-Graham, K. F.
通讯作者：
Raab-Graham, K. F.
影响因子：
3
作者：
Wang, Q;Song, CC;Li, CCH
通讯作者：
Li, CCH
影响因子：
16.2
作者：
Turecek, Rostislav;Schwenk, Jochen;Bettler, Bernhard
通讯作者：
Bettler, Bernhard
影响因子：
25
作者：
Schwenk, Jochen;Perez-Garci, Enrique;Fakler, Bernd
通讯作者：
Fakler, Bernd
影响因子：
64.8
作者：
Schwenk, Jochen;Metz, Michaela;Bettler, Bernhard
通讯作者：
Bettler, Bernhard