Tumor promoters enhance basal and growth hormone releasing factor stimulated cyclic AMP levels in anterior pituitary cells.
Tumor promoters enhance basal and growth hormone releasing factor stimulated cyclic AMP levels in anterior pituitary cells.
复制标题
肿瘤促进剂增强垂体前叶细胞中基础和生长激素释放因子刺激的环AMP水平。
DOI：
10.1016/0006-291x(85)90165-2
复制
发表时间：
1985
影响因子：
3.1
通讯作者：
Canonico,PL
中科院分区：
文献类型：
--
作者：
Cronin,MJ;Canonico,PL
肿瘤促进剂，例如佛波酯和teleocidin，增强了生长激素释放因子增加垂体环AMP水平的能力。肿瘤促进剂的这种作用是浓度依赖性的，可以在5分钟内观察到，并在4小时内结束。无活性的肿瘤促进剂（即4-α-二癸酸酯）对该系统没有影响，而合成的二酰基甘油（即1-油酰基-2-乙酰基甘油）则模仿肿瘤促进剂的作用。由于已知肿瘤促进剂和二酰甘油都会刺激蛋白激酶 C，我们认为这种钙和磷脂依赖性蛋白激酶 C 可以增强生长激素释放因子受体激活环 AMP 生成系统的能力。
Tumor promoters, such as phorbol esters and teleocidin, amplified the ability of growth hormone releasing factor to increase pituitary cyclic AMP levels. This effect of tumor promoters was concentration-dependent, could be observed in 5 minutes, and was over by 4 hours. Inactive tumor promoters (i.e., 4-alpha-didecanoate) had no effect on this sytem, whereas a synthetic diacylglycerol (i.e., 1-oleoly-2-acetyl glycerol), mimicked the action of tumor promoters. Due to the known stimulation of protein kinase C by both tumor promoters and diacylglycerols, we suggest that this calcium and phospholipid dependent protein kinase C can enhance the ability of the growth hormone releasing factor receptor to activate the cyclic AMP generating system.