Histone lysine demethylases in Drosophila melanogaster.
Histone lysine demethylases in Drosophila melanogaster.
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DOI：
10.1080/19336934.2015.1074787
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发表时间：
2015
期刊：
影响因子：
1.2
通讯作者：
Pile LA
中科院分区：
文献类型：
--
作者：
Holowatyj A;Yang ZQ;Pile LA
染色质结构的表观遗传调控是真核生物的一个基本过程。调控因子包括DNA甲基化、microRNA和染色质修饰。在染色质修饰剂中，一类可以通过去除甲基标记功能性结合和修饰染色质的酶是组蛋白赖氨酸脱甲基酶。在这里，我们总结了目前的研究结果的13个已知的组蛋白赖氨酸去甲基化酶在果蝇，并讨论了这些组蛋白修饰酶在维持基因组功能的关键作用。此外，由于组蛋白去甲基化酶失调已被确定在癌症中，我们讨论了使用果蝇作为模型系统来研究肿瘤发生的优势。
Epigenetic regulation of chromatin structure is a fundamental process for eukaryotes. Regulators include DNA methylation, microRNAs and chromatin modifications. Within the chromatin modifiers, one class of enzymes that can functionally bind and modify chromatin, through the removal of methyl marks, is the histone lysine demethylases. Here, we summarize the current findings of the 13 known histone lysine demethylases in Drosophila melanogaster, and discuss the critical role of these histone-modifying enzymes in the maintenance of genomic functions. Additionally, as histone demethylase dysregulation has been identified in cancer, we discuss the advantages for using Drosophila as a model system to study tumorigenesis.