Complex span tasks and hippocampal recruitment during working memory
Complex span tasks and hippocampal recruitment during working memory
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DOI：
10.1016/j.neuroimage.2010.12.033
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发表时间：
2011-03-15
期刊：
影响因子：
5.7
通讯作者：
Miller, L. Stephen
中科院分区：
文献类型：
--
作者：
Faraco, Carlos Cesar;Unsworth, Nash;Miller, L. Stephen
工作记忆（WM）系统对于执行需要注意的非自动信息处理的日常功能至关重要。然而，它与长期记忆（LTM）的相互作用备受争议。在这里，我们使用功能磁共振成像来检查是否一个流行的复杂的WM跨度任务，被认为是强制位移的注意力集中到LTM，招募内侧颞区通常与LTM功能在更大的程度上，并在不同的方式比传统的WM任务在WM编码和维护，当参与者执行操作跨度（OSPAN）任务和算术任务时，获得了fMRI扫描。结果表明，这两项任务的性能导致显着的激活区域通常与WM功能。更重要的是，在海马中观察到显著的双侧激活，表明它在WM编码和维持期间被招募。右后海马激活OSPAN比算术。Peristimulus图表明，一个可能的专业化的功能，双边后部海马和更大的参与左侧的WM性能。在这个区域内的回忆时程活动暗示在复杂的跨度在LTM参与。(C)2010年爱思唯尔公司All rights reserved.
The working memory (WM) system is vital to performing everyday functions that require attentive, non-automatic processing of information. However, its interaction with long term memory (LTM) is highly debated. Here, we used fMRI to examine whether a popular complex WM span task, thought to force the displacement of to-be-remembered items in the focus of attention to LTM, recruited medial temporal regions typically associated with LTM functioning to a greater extent and in a different manner than traditional neuroimaging WM tasks during WM encoding and maintenance, fMRI scans were acquired while participants performed the operation span (OSPAN) task and an arithmetic task. Results indicated that performance of both tasks resulted in significant activation in regions typically associated with WM function. More importantly, significant bilateral activation was observed in the hippocampus, suggesting it is recruited during WM encoding and maintenance. Right posterior hippocampus activation was greater during OSPAN than arithmetic. Persitimulus graphs indicate a possible specialization of function for bilateral posterior hippocampus and greater involvement of the left for WM performance. Recall time-course activity within this region hints at LTM involvement during complex span. (C) 2010 Elsevier Inc. All rights reserved.