Biomaterial-based delivery for skeletal muscle repair.
Biomaterial-based delivery for skeletal muscle repair.
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DOI：
10.1016/j.addr.2014.09.008
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发表时间：
2015-04
影响因子：
16.1
通讯作者：
Mooney, David J.
中科院分区：
文献类型：
--
作者：
Cezar, Christine A.;Mooney, David J.
关键词：
骨骼肌具有针对轻微损伤的显着再生能力，但导致体积肌肉损失的严重损伤可能导致广泛且不可逆的纤维化、疤痕和肌肉功能丧失。在早期的临床试验中，肌肉注射培养的成肌细胞被证明是一种安全但无效的细胞疗法，可能是由于注射细胞的快速死亡、迁移不良和免疫排斥。近年来，适当的治疗细胞类型和培养技术改善了移植后祖细胞的植入。重要的是，协同调节卫星细胞命运的几个关键生物物理和生化线索的识别，为细胞指导性生物材料的开发铺平了道路，这些生物材料可作为细胞的递送载体，促进体内再生。设计用于在空间和时间上模拟卫星细胞生态位的材料载体对于严重受损的骨骼肌的完全再生可能特别重要。
Skeletal muscle possesses a remarkable capacity for regeneration in response to minor damage, but severe injury resulting in a volumetric muscle loss can lead to extensive and irreversible fibrosis, scarring, and loss of muscle function. In early clinical trials, the intramuscular injection of cultured myoblasts was proven to be a safe but ineffective cell therapy, likely due to rapid death, poor migration, and immune rejection of the injected cells. In recent years, appropriate therapeutic cell types and culturing techniques have improved progenitor cell engraftment upon transplantation. Importantly, the identification of several key biophysical and biochemical cues that synergistically regulate satellite cell fate has paved the way for the development of cell-instructive biomaterials that serve as delivery vehicles for cells to promote in vivo regeneration. Material carriers designed to spatially and temporally mimic the satellite cell niche may be of particular importance for the complete regeneration of severely damaged skeletal muscle.
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