The Pharmacokinetics and Pharmacology of Oral Diltiazem in Normal Volunteers
The Pharmacokinetics and Pharmacology of Oral Diltiazem in Normal Volunteers
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正常志愿者口服地尔硫卓的药代动力学和药理学
DOI：
10.1002/j.1552-4604.1981.tb01778.x
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发表时间：
1981
期刊：
影响因子：
--
通讯作者：
R. Zelis
中科院分区：
文献类型：
--
作者：
E. Kinney;R. Moskowitz;R. Zelis
摘要：口服地尔硫卓正越来越多地用于治疗金属丝裂伤心绞痛。本研究调查了正常男性志愿者口服不同剂量地尔硫卓后的药代动力学、心电图效应和血压反应。选择的剂量分别为30、60、90和120毫克。13名受试者服用30毫克。12名受试者服用60 mg，10名受试者服用地尔硫卓90 mg，4名受试者服用120 mg地尔硫卓AUC，60、90和120 mg剂量分别为565、984和1258 ng/ml.hr。每次给药后，tç、β和Tmax的值相似。
Abstract: Oral diltiazem is being used increasingly in the treatment of Prinzmetal's angina. This study investigated the pharmacokinetics, electrocardiographic effects, and blood pressure response of normal male volunteers to various single oral doses of diltiazem. Doses selected were 30, 60, 90, and 120 mg. Thirteen subjects received 30 mg. 12 subjects received 60 mg, 10 subjects received 90 mg, diltiazem, and four subjects received 120 mg diltiazem AUCs for the 60, 90, and 120 mg doses were 565, 984, and 1258 ng/ml · hr, respectively. The values for t½, β, and tmax were similar after each dosing.