An Estimate of the Incidence of Prostate Cancer in Africa: A Systematic Review and Meta-Analysis.
An Estimate of the Incidence of Prostate Cancer in Africa: A Systematic Review and Meta-Analysis.
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DOI：
10.1371/journal.pone.0153496
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发表时间：
2016
期刊：
影响因子：
3.7
通讯作者：
Ayo CK
中科院分区：
文献类型：
--
作者：
Adeloye D;David RA;Aderemi AV;Iseolorunkanmi A;Oyedokun A;Iweala EE;Omoregbe N;Ayo CK
前列腺癌 (PCa) 被评为全球男性第二大常见癌症和第六大癌症死亡原因。报告显示，与世界其他地区的男性相比，非洲男性患前列腺癌的比例更高。由于癌症登记系统薄弱，准确描述非洲前列腺癌的负担仍然相当困难。我们系统地回顾了非洲前列腺癌的文献，并根据该地区的现有数据提供了非洲大陆前列腺癌的发病率。对 1980 年 1 月至 2015 年 6 月期间的 Medline、EMBASE 和 Global Health 进行了系统文献检索，同时还对 Google Scholar、国际癌症登记协会 (IACR)、国际癌症研究机构 (IARC) 和 WHO 非洲地区网站进行了额外检索，以查找估计非洲任何地点 PCa 发病率的研究。在评估了选定研究的质量和一致性后，我们提取了 PCa 的发病率并进行了随机效应荟萃分析。我们的检索返回了 9766 条记录，其中 40 项研究分布在 16 个非洲国家，符合我们的选择标准。我们估计 PCa 的汇总发病率为每 100,000 人 22.0 例（95% CI：19.93–23.97），并且报告的中位发病率为每 100,000 人 19.5 例。我们观察到随着年龄的增长以及所涵盖的主要年份，前列腺癌的发病率呈上升趋势。有效的癌症登记和广泛的研究对于适当量化非洲前列腺癌负担至关重要。我们希望我们的研究结果可以进一步帮助确定相关差距，并有助于提高针对非洲前列腺癌的知识、研究和干预措施。
Prostate cancer (PCa) is rated the second most common cancer and sixth leading cause of cancer deaths among men globally. Reports show that African men suffer disproportionately from PCa compared to men from other parts of the world. It is still quite difficult to accurately describe the burden of PCa in Africa due to poor cancer registration systems. We systematically reviewed the literature on prostate cancer in Africa and provided a continent-wide incidence rate of PCa based on available data in the region. A systematic literature search of Medline, EMBASE and Global Health from January 1980 to June 2015 was conducted, with additional search of Google Scholar, International Association of Cancer Registries (IACR), International Agency for Research on Cancer (IARC), and WHO African region websites, for studies that estimated incidence rate of PCa in any African location. Having assessed quality and consistency across selected studies, we extracted incidence rates of PCa and conducted a random effects meta-analysis. Our search returned 9766 records, with 40 studies spreading across 16 African countries meeting our selection criteria. We estimated a pooled PCa incidence rate of 22.0 (95% CI: 19.93–23.97) per 100,000 population, and also reported a median incidence rate of 19.5 per 100,000 population. We observed an increasing trend in PCa incidence with advancing age, and over the main years covered. Effective cancer registration and extensive research are vital to appropriately quantifying PCa burden in Africa. We hope our findings may further assist at identifying relevant gaps, and contribute to improving knowledge, research, and interventions targeted at prostate cancer in Africa.