Arterial alterations in severely obese children with obstructive sleep apnoea
Arterial alterations in severely obese children with obstructive sleep apnoea
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DOI：
10.3109/17477160903473705
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发表时间：
2010-05-01
影响因子：
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通讯作者：
Tounian, Patrick
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文献类型：
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作者：
Dubern, Beatrice;Aggoun, Yacine;Tounian, Patrick
背景肥胖成人的阻塞性睡眠呼吸暂停（OSA）与心血管疾病相关，与肥胖无关。肥胖儿童存在血管改变，可能构成成年期心血管疾病发展的第一阶段。Objective.探讨肥胖儿童阻塞性睡眠呼吸暂停与早期动脉改变的关系。设计前瞻性队列的横断面研究。患者共有51名严重肥胖儿童在教学医院门诊接受治疗。测量.进行多导睡眠描记术。我们测量了颈总动脉内膜中层厚度和增量弹性模量（Einc），以评估颈总动脉的力学特性。通过测量肱动脉的流量介导的扩张和三硝酸甘油介导的扩张（GTNMD）来评价动脉内皮功能。结果共有24名（47%）儿童的去饱和指数（DI）> 10/h，7名（14%）儿童的呼吸事件指数> 10/h。DI > 10/h与Einc值显著较高相关（4.0 +/- 0.5 vs. 2.4 +/- 0.4 mm Hg
Background. Obstructive sleep apnoea (OSA) in obese adults is associated with cardiovascular disease independently of obesity. Vascular alterations exist in children with obesity and may constitute the first stage in the development of adulthood cardiovascular disease. Objective. To investigate the relationship between OSA and early arterial alterations in obese children. Design. Cross-sectional study of a prospective cohort. Patients. A total of 51 children with severe obesity managed at a teaching hospital outpatient clinic. Measurements. Polysomnography was performed. We measured the intima-media thickness and incremental elastic modulus (Einc) to assess the mechanical characteristics of the common carotid artery. Arterial endothelial function was evaluated by measuring flow-mediated dilation and glyceryl trinitrate-mediated dilation (GTNMD) of the brachial artery. Results. A total of 24 (47%) children had a desaturation index (DI) > 10/h and 7 (14%) had a respiratory event index > 10/h. DI > 10/h was associated with significantly higher values of Einc (4.0 +/- 0.5 vs. 2.4 +/- 0.4 mm Hg