ISOLATION AND IDENTIFICATION OF CONIDIAL GERMINATION FACTOR OF NEUROSPORA-CRASSA
ISOLATION AND IDENTIFICATION OF CONIDIAL GERMINATION FACTOR OF NEUROSPORA-CRASSA
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DOI：
10.1128/jb.127.1.135-140.1976
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发表时间：
1976-01-01
影响因子：
3.2
通讯作者：
WILLIAMS, NP
中科院分区：
文献类型：
--
作者：
HOROWITZ, NH;CHARLANG, G;WILLIAMS, NP
粗毛拟青霉分生孢子在低水活度溶液中失去的发芽必需物质(发芽因子[GF])已被分离和鉴定为一组铁转运化合物，或称铁铬。分生孢子的主要含铁色素是铁蛋白，一种环状六肽。一种密切相关的物质，铁铬C，被初步确定为次要成分。同样的物质也存在于菌丝体的提取物中，以及少量的第三铁铬，这一物质尚未被鉴定。培养滤液的生长因子活性是由辅原蛋白引起的，辅原蛋白是唯一一种与粗毛拟青霉同源的铁色素。
The germination-essential substance (germination factor [GF]) that is lost from conidia of N. crassa on exposure to solutions of low water activity has been isolated and identified as a group of iron-transport compounds, or siderochromes. The principal siderochrome of conidia is ferricrocin, a cyclic hexapeptide. A closely related substance, ferrichrome C, is tentatively identified as a minor constituent. The same substances are also present in extracts of mycelium along with small amounts of a 3rd siderochrome, which has not been identified. The GF activity of culture filtrates is due to coprogen, the only siderochrome previously identified with N. crassa.