Retinal vessel diameters and obesity: A population-based study in older persons
Retinal vessel diameters and obesity: A population-based study in older persons
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DOI：
10.1038/oby.2006.27
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发表时间：
2006-02-01
期刊：
影响因子：
6.9
通讯作者：
Mitchell, Paul
中科院分区：
文献类型：
--
作者：
Wang, Jie J.;Taylor, Bronwen;Mitchell, Paul
目的：肥胖与大血管粥样硬化和糖尿病有关。它与微血管变化的关系还不是很清楚。我们在老年人群中调查了视网膜血管直径、血管壁征象和BMI之间的关系。研究方法和程序：在澳大利亚蓝山眼科研究的基线下，对3654名年龄在49岁以上的人拍摄了视网膜照片。测量小动脉和小静脉直径。从右眼的数字化视网膜照片。体重指数以体重(公斤)/身高(米(2))计算。偶发肥胖的定义是体重指数：基线时为5 30，但5年后为30。显著的体重增加被定义为在5年期间BMI增加2+SD(4个或更多单位)。结果：在基线时，该人群的平均BMI为26.1(+/-4.6)。在为期5年的检查中，177人(1773人中有10.0%)发生了偶发肥胖，136人(2143人中有6.4%)体重显著增加。在调整了年龄、性别、吸烟、甘油三酯水平和平均动脉压后，视网膜静脉直径较大的人发生肥胖的风险更高(优势比为1.8；95%可信区间为1.0至3.1，与最高的与最低的静脉直径五分位数相比)和显著的体重增加(优势比为1.7；95%可信区间为0.9至3.2)。这些关联随着基线BMI的进一步调整而减弱。微动脉直径与基线或BMI变化无关。讨论：视网膜静脉直径较宽与肥胖风险相关，与高血压、糖尿病、血脂和吸烟无关。这些数据可能支持微血管功能受损在体重增加过程中的作用。
Objective: Obesity is linked with large vessel atherosclerosis and diabetes. Its association with microvascular changes is less clear. We investigated the associations among retinal vessel diameters, vessel wall signs, and BMI in an older population.Research Methods and Procedures: Retinal photographs were taken on 3654 persons aged 49+ years at baseline of the Blue Mountains Eye Study in Australia. Arteriolar and venular diameters were measured. from digitized retinal photographs of the right eyes. BMI was calculated as weight (kilograms)/height (meters(2)). Incident obesity was defined in persons with BMI :5 30 at baseline but >30 after 5 years. A significant weight gain was defined as an increase in BMI of 2+ SDs (4 or more units) over the 5-year period.Results: At baseline, mean BMI was 26.1 (+/- 4.6) in this population. At 5-year examinations, 177 (10.0% of 1773 at risk) developed incident obesity, and 136 (6.4% of 2143 at risk) had significant weight gain. After adjusting for age, sex, smoking, triglyceride levels, and mean arterial blood pressure, persons with wider retinal venular diameters had a higher risk of incident obesity (odds ratio, 1.8; 95% confidence interval, 1.0 to 3.1, comparing the highest with lowest venular diameter quintiles) and significant weight gain (odds ratio, 1.7; 95% confidence interval, 0.9 to 3.2). These associations were attenuated with further adjustment for baseline BMI. Arteriolar diameter was unrelated with baseline or change in BMI.Discussion: Wider retinal venular diameter is associated with risk of obesity, independent of hypertension, diabetes, lipids, and cigarette smoking. These data may support a role for impaired microvascular function in the course of weight gain.