The CLAVATA1-related BAM1, BAM2 and BAM3 receptor kinase-like proteins are required for meristem function in Arabidopsis
The CLAVATA1-related BAM1, BAM2 and BAM3 receptor kinase-like proteins are required for meristem function in Arabidopsis
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DOI：
10.1111/j.1365-313x.2005.02592.x
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发表时间：
2006-01-01
期刊：
影响因子：
7.2
通讯作者：
Clark, SE
中科院分区：
文献类型：
--
作者：
DeYoung, BJ;Bickle, KL;Clark, SE
植物茎和花分生组织的器官形成需要维持一群位于中心的干细胞和位于外周的子细胞的分化。拟南芥中的CLAVATA（CLV）基因产物，包括CLV1受体激酶，通过促进分生组织侧翼干细胞的分化来调节这一过程。在这里，我们分析了CLV1相关的BAM 1（来自几乎没有任何分生组织1），BAM 2和BAM 3受体样激酶的发育作用。这些受体的功能丧失等位基因导致表型与茎和花分生组织干细胞的丧失一致，表明它们的发育作用与CLV1相反。这些密切相关的受体通过具有广泛的表达模式和多种发育作用而进一步区别于CLV 1，CLV 1的表达和功能是高度特异性的。这些包括BAM 1，BAM 2和BAM 3在叶内的高阶维管链的发展中的需要，以及对叶的形状，大小和对称性的相关控制。此外，BAM 1、BAM 2和BAM 3是雄配子体发育以及胚珠规格和功能所必需的。值得注意的是，CLV1和BAM受体在分生组织和器官发育中的不同作用在很大程度上是由表达模式的差异驱动的。
Organ formation at shoot and flower meristems in plants requires the maintenance of a population of centrally located stem cells and the differentiation of peripherally located daughter cells. The CLAVATA (CLV) gene products in Arabidopsis, including the CLV1 receptor-kinase, regulate this process by promoting the differentiation of stem cells on the meristem flanks. Here, we have analyzed the developmental roles of the CLV1-related BAM1 (derived from barely any meristem 1), BAM2 and BAM3 receptor-like kinases. Loss-of-function alleles of these receptors lead to phenotypes consistent with the loss of stem cells at the shoot and flower meristem, suggesting that their developmental role is opposite to that of CLV1. These closely related receptors are further distinguished from CLV1, whose expression and function is highly specific, by having broad expression patterns and multiple developmental roles. These include a requirement for BAM1, BAM2 and BAM3 in the development of high-ordered vascular strands within the leaf and a correlated control of leaf shape, size and symmetry. In addition, BAM1, BAM2 and BAM3 are required for male gametophyte development, as well as ovule specification and function. Significantly, the differing roles of CLV1 and BAM receptors in meristem and organ development are largely driven by differences in expression patterns.