Multilayered Microfluidic Paper-Based Devices: Characterization, Modeling, and Perspectives
Multilayered Microfluidic Paper-Based Devices: Characterization, Modeling, and Perspectives
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DOI：
10.1021/acs.analchem.9b01112
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发表时间：
2019-07-16
影响因子：
7.4
通讯作者：
Dandy, David S.
中科院分区：
文献类型：
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作者：
Channon, Robert B.;Nguyen, Michael P.;Dandy, David S.
微流控纸基分析设备(MUPAD)是简单但强大的分析工具，由于其相对于更传统的监测工具的许多优点，最近正受到极大的关注。这些要求包括廉价、便携、无泵，以及能够存储试剂。这些设备的一个主要局限性是流速慢，这是由纤维素纸亲水性毛孔中的毛细作用控制的。最近的研究已经通过在两张紧密间隔的纸片之间产生间隙或通道来提高MU衬垫中的流速。这种多层格式为新的应用和检测方案提供了MU衬垫，其中大间隙尺寸(>；300微米)提供的流速至少是单层MU衬垫的169倍，但不符合已建立的多孔材料中流体传输的数学模型，例如经典的Lucas-ashburn方程。在本研究中，通过实验研究和分析模型来阐明这些装置中快速流速背后的驱动力。本文研究了系统流体动力学的一系列假设，建立了考虑粘性耗散的多层金属衬垫内流量预测的理论模型。器件取向、样品添加方法和间隙高度被发现是模拟多层器件中的渗吸的关键因素。
Microfluidic paper-based analytical devices (mu PADs) are simple but powerful analytical tools that are gaining significant recent attention due to their many advantages over more traditional monitoring tools. These include being inexpensive, portable, pump free, and having the ability to store reagents. One major limitation of these devices is slow flow rates, which are controlled by capillary action in the hydrophilic pores of cellulosic paper. Recent investigations have advanced the flow rates in mu PADs through the generation of a gap or channel between two closely spaced paper sheets. This multilayered format has opened up mu PADs to new applications and detection schemes, where large gap sizes (>300 mu m) provide at least 169X faster flow rates than single-layer mu PADs, but do not conform to established mathematical models for fluid transport in porous materials, such as the classic Lucas-Washburn equation. In the present study, experimental investigations and analytical modeling are applied to elucidate the driving forces behind the rapid flow rates in these devices. We investigate a range of hypotheses for the systems fluid dynamics and establish a theoretical model to predict the flow rate in multilayered mu PADs that takes into account viscous dissipation within the paper. Device orientation, sample addition method, and the gap height are found to be critical concerns when modeling the imbibition in multilayered devices.