Increase in the beta subunit of human TSH in hypothyroid serum after thyrotropin releasing hormone.
Increase in the beta subunit of human TSH in hypothyroid serum after thyrotropin releasing hormone.
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促甲状腺激素释放激素后，甲状腺功能减退症血清中人 TSH β 亚基增加。
DOI：
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发表时间：
1973
影响因子：
5.8
通讯作者：
F. Maloof
中科院分区：
文献类型：
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作者：
I. Kourides;B. Weintraub;E. Ridgway;F. Maloof
本文检测了11例原发性甲状腺功能减退症患者血清中人促甲状腺激素β亚基(hTSH-β)。11例患者经促甲状腺激素释放激素治疗后，血清hTSH-β均升高。在TRH后多次研究的患者中，有5名患者早在TRH后5分钟就出现了hTSH-β升高。HTSH-β上升较快，达到峰值的时间早于hTSH。这些数据表明，在原发性甲状腺功能减退症患者中，hTSH-β的分泌是对促甲状腺激素释放激素的反应。
ABSTRACT The beta subunit of human thyrotropin (hTSH-β) was detected in the serum of 9 of 11 patients with primary hypothyroidism. After the administration of thyrotropin releasing hormone (TRH), there was an increase in serum hTSH-β in all 11 patients. Five of the patients studied at multiple intervals after TRH showed an increase in hTSH-β as early as 5 minutes after TRH. HTSH-β rose more rapidly and reached a peak earlier than hTSH. The data suggest that hTSH-β is secreted in response to TRH in patients with primary hypothyroidism.