The role of omega-3 in the prevention and treatment of sarcopenia
The role of omega-3 in the prevention and treatment of sarcopenia
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DOI：
10.1007/s40520-019-01146-1
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发表时间：
2019-06-01
影响因子：
4
通讯作者：
Gielen, Evelien
中科院分区：
文献类型：
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作者：
Dupont, Jolan;Dedeyne, Lenore;Gielen, Evelien
肌肉减少症是一种老年综合征，由于人口老龄化而日益重要。众所周知，它在发病率、死亡率和社会经济成本方面造成了重大负担。因此，需要适当的预防和治疗策略。渐进式阻力训练和蛋白质补充目前被推荐用于预防和治疗肌肉减少症。ω-3多不饱和脂肪酸（PUFA）由于其抗炎特性而可能是用于肌肉减少症的替代治疗剂，其靶向“炎症”，即年龄相关的慢性低度炎症，其被认为有助于肌肉减少症的发展。此外，omega-3 PUFA还可能通过激活mTOR信号传导和降低胰岛素抵抗对肌肉具有合成代谢作用。本叙述性综述概述了目前关于omega-3 PUFA及其在预防和治疗肌肉减少症中的作用的知识。我们的结论是，越来越多的证据表明，补充omega-3 PUFAs对肌肉减少的老年人有有益的影响，这可能会增加运动和/或蛋白质补充剂的效果。然而，治疗和预防肌肉减少症的确切剂量、频率和使用（单独或联合）仍需进一步探索。
Sarcopenia is a geriatric syndrome with increasing importance due to the aging of the population. It is known to impose a major burden in terms of morbidity, mortality and socio-economic costs. Therefore, adequate preventive and treatment strategies are required. Progressive resistance training and protein supplementation are currently recommended for the prevention and treatment of sarcopenia. Omega-3 polyunsaturated fatty acids (PUFAs) might be an alternative therapeutic agent for sarcopenia due to their anti-inflammatory properties, which target the inflammaging', the age-related chronic low-grade inflammation which is assumed to contribute to the development of sarcopenia. In addition, omega-3 PUFAs may also have an anabolic effect on muscle through activation of the mTOR signaling and reduction of insulin resistance. This narrative review provides an overview of the current knowledge about omega-3 PUFAs and their role in the prevention and treatment of sarcopenia. We conclude that there is growing evidence for a beneficial effect of omega-3 PUFAs supplementation in sarcopenic older persons, which may add to the effect of exercise and/or protein supplementation. However, the exact dosage, frequency and use (alone or combined) in the treatment and prevention of sarcopenia still need further exploration.