Minus-lens-stimulated accommodative amplitude decreases sigmoidally with age: A study of objectively measured accommodative amplitudes from age 3
Minus-lens-stimulated accommodative amplitude decreases sigmoidally with age: A study of objectively measured accommodative amplitudes from age 3
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DOI：
10.1167/iovs.07-1492
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发表时间：
2008-07-01
影响因子：
4.4
通讯作者：
Manny, Ruth E.
中科院分区：
文献类型：
--
作者：
Anderson, Heather A.;Hentz, Gloria;Manny, Ruth E.
目的。按年龄预测调节幅度的指南通常基于高估调节反应的主观俯卧撑测试数据。使用客观测量的研究已经确定了成人的预期振幅，但儿童的预期振幅仍然未知。在本研究中，使用客观方法测量了广泛年龄范围的个体的调节幅度，以从年龄开始定义幅度与年龄的关系。 3.方法。对 140 名 3 至 40 岁受试者的调节反应进行了测量。使用 Grand Seiko 自动验光仪（日本香川县 RyuSyo 工业有限公司）进行测量，受试者通过增加倍率的负镜片观察 33 厘米处的高对比度目标，直到反应显示调节不再进一步增加。 结果。每个受试者的最大调节幅度按年龄绘制，曲线函数拟合数据：y = 7.33-0.0035(age-3)(2) (P < 0.001)。拟合的正切分析表明，调节幅度在 20 岁之前保持相对稳定。然后将本研究的数据与之前对 70 岁以下成人的研究的客观幅度进行汇总。S 形函数对数据进行拟合：y = 7.083/(1 + e([0.2031(age-36.2))-(0.6109])) (P < 0.001)。 S 形函数表明 20 岁以下振幅相对稳定，20 至 50 岁之间快速线性下降，50 岁以上逐渐减少到 0。结论。这些数据表明，调节幅度从 3 年到 40 年呈曲线下降。与之前研究的数据相结合，S 形函数描述了整个生命周期的总体趋势，最大下降发生在 20 至 50 年间。
PURPOSE. Guidelines for predicting accommodative amplitude by age are often based on subjective push-up test data that overestimate the accommodative response. Studies in which objective measurements were used have defined expected amplitudes for adults, but expected amplitudes for children remain unknown. In this study, objective methods were used to measure accommodative amplitude in a wide age range of individuals, to define the relationship of amplitude and age from age 3.METHODS. Accommodative responses were measured in 140 subjects aged 3 to 40 years. Measurements were taken with the Grand Seiko autorefractor (RyuSyo Industrial Co., Ltd., Kagawa, Japan) as the subjects viewed a high-contrast target at 33 cm through minus lenses of increasing power until the responses showed no further increase in accommodation.RESULTS. The maximum accommodative amplitude of each subject was plotted by age, and a curvilinear function fit to the data: y = 7.33-0.0035(age-3)(2) (P < 0.001). Tangent analysis of the fit indicated that the accommodative amplitude remained relatively stable until age 20. Data from this study were then pooled with objective amplitudes from previous studies of adults up to age 70. A sigmoidal function was fit to the data: y = 7.083/(1 + e([0.2031(age-36.2))-(0.6109])) (P < 0.001). The sigmoidal function indicated relatively stable amplitudes below age 20 years, a rapid linear decline between 20 and 50 years, and a taper to 0 beyond 50 years.CONCLUSIONS. These data indicate that accommodative amplitude decreases in a curvilinear manner from 3 to 40 years. When combined with data from previous studies, a sigmoidal function describes the overall trend throughout life with the biggest decrease occurring between 20 and 50 years.