Model for age-dependent decline in dopamine transporter.
Model for age-dependent decline in dopamine transporter.
复制标题
多巴胺转运蛋白年龄依赖性下降模型。
DOI：
10.1007/s12149-019-01388-z
复制
发表时间：
2019
期刊：
影响因子：
2.6
通讯作者：
Ogawa S.
中科院分区：
文献类型：
--
作者：
Kameyama M;Umeda-Kameyama Y;Ogawa S.
我们怀着极大的兴趣阅读了Roberts等人发表在《核医学年鉴》上的文章[1]。在老年人中，多巴胺转运体(DAT)不会随着年龄的增长而下降，这一拟议的论点将影响许多诊断老年患者的核医学医生。我们认为这篇论文是合理的，但我们也认为所提供的数据是不确定的。线性回归是一种可以接受的分析工具，但它的局限性应该得到承认。一个解释这种非线性关系的模型会更可取。较大的决定系数(R2)将提供令人信服的论据。然而，只能计算有限数量的方程。在没有理论模型的情况下，原则上无法确定最佳拟合方程。在数学中，有许多函数在一定范围内与给定函数任意接近。双线性关系有时可以合并为指数关系。基于模型[2]的红细胞肌酸和平均红细胞年龄之间的半对数关系可能比先前提出的双线性关系更可取。随机消除dat的泊松过程模型将为指数关系提供基础，例如放射性核素。指数关系确保SBR为正值。
We read with great interest the article by Roberts et al.[1] published in the Annals of Nuclear Medicine. The proposed thesis that dopamine transporter (DaT) does not decrease with age in older people would affect many nuclear medicine physicians who diagnose older patients. We feel that the thesis is reasonable; however, we also feel that the data presented is inconclusive.Linear regression is an acceptable tool for analysis; however, its limitation should be recognized. A model to explain the non-linear relationship would be preferable. A large coefficient of determination (R2) would provide a convincing argument. However, merely finite number of equations can be evaluated. The best fit equation cannot be determined in principle without a theoretical model. In mathematics, there are numerous functions that are arbitrarily close to a given function within a certain range. A bi-linear relationship can be sometimes merged into an exponential relationship. A semi-log relationship between erythrocyte creatine and mean erythrocyte age based on a model [2] might be preferable to the previously proposed bi-linear relationship. A poisson process model of random elimination of DaT would provide a basis for an exponential relationship, such as a radionuclide. An exponential relationship assures a positive value for SBR.