HEMOLYSIS OF ERYTHROCYTES BY ANTIBACTERIAL PRESERVATIVES .3. INFLUENCE OF DIMETHYL SULFOXIDE ON HEMOLYTIC ACTIVITY OF PHENOL
HEMOLYSIS OF ERYTHROCYTES BY ANTIBACTERIAL PRESERVATIVES .3. INFLUENCE OF DIMETHYL SULFOXIDE ON HEMOLYTIC ACTIVITY OF PHENOL
复制标题
DOI：
10.1002/jps.2600550704
复制
发表时间：
1966-01-01
影响因子：
3.8
通讯作者：
LEAKE, WF
中科院分区：
文献类型：
--
作者：
ANSEL, HC;LEAKE, WF
研究了二甲基亚砜（DMSO）对苯酚体外溶血活性的影响。尽管DMSO可自由穿透红细胞膜，并且在高浓度下对红细胞具有破坏性，但它大大降低了苯酚诱导的洗涤和未洗涤红细胞溶血。这种干扰是通过与苯酚的化学相互作用或通过直接的细胞效应表现出来的。
The influence of dimethyl sulfoxide (DMSO) on the hemolytic activity of phenol was investigated in vitro. Although DMSO freely penetrates the erythrocytic membrane and, in high concentrations, is destructive to red cells, it greatly reduced phenol-induced hemolysis of both washed and unwashed erythrocytes. This interference was manifested through chemical interaction with phenol or through a direct cellular effect.