Semiconducting Nanocomposite with AIEgen-Triggered Enhanced Photoluminescence and Photodegradation for Dual-Modality Tumor Imaging and Therapy
Semiconducting Nanocomposite with AIEgen-Triggered Enhanced Photoluminescence and Photodegradation for Dual-Modality Tumor Imaging and Therapy
复制标题
具有 AIEgen 触发增强光致发光和光降解作用的半导体纳米复合材料，用于双模态肿瘤成像和治疗
DOI：
10.1002/adfm.201903733
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发表时间：
2019-07-19
影响因子：
19
通讯作者：
Wang, Zhuo
中科院分区：
文献类型：
--
作者：
Li, Yawen;Liu, Zitong;Wang, Zhuo
半导体聚合物纳米粒子（SPN）具有潜在的生物应用前景。虽然一些SPN作为光热和光声试剂具有显著的光热转换效率（PCE），但其他SPN作为光致发光试剂提供高荧光产率。然而，SPN中的能量平衡分布抑制了它们在光致发光/光声（PL/PA）双模态成像中的成功应用。此外，SPN在体内的超稳定性可能会对生物体造成损害。本工作报告纳米复合半导体聚合物和四苯乙烯纳米粒子（STNP）构建的半导体聚合物（SP）和四苯乙烯聚集诱导发光（TPE AIEgens）。SP SPC 10具有良好的光热转换能力，AIEgen TPBM支持STNP的增强光致发光。结果表明，STNP可作为PL/PA双模态显像剂。PL模式的信噪比（S/N）达到8.7，PA模式的成像深度为5.8 mm。STNP中的SPC 10在90 mW cm（-2）白色光照射下可在6 h内分解，无需任何其他试剂。此外，STNP足以用于基于光热疗法的异种移植4 T1荷瘤小鼠的治疗。纳米复合STNP实现了优化的双模态PL/PA成像和AIEgen触发的SPN原位光降解。这些性质表明STNP在临床诊断和非侵入性治疗中的重要潜力。
Semiconducting polymer nanoparticles (SPNs) have potential in biological applications. While some SPNs have significant photothermal conversion efficiencies (PCEs) as photothermal and photoacoustic agents, other SPNs offer high fluorescence yields as photoluminescent agents. However, the energy balance distribution in SPNs inhibits their successful applications in photoluminescence/photoacoustic (PL/PA) dual-modality imaging. Additionally, the ultrastability of SPNs in vivo may cause damage to organisms. This work reports nanocomposite semiconducting polymer and tetraphenylethene nanoparticles (STNPs) constructed by semiconducting polymers (SPs) and tetraphenylethene aggregation-induced emission luminogens (TPE AIEgens). The SP SPC10 endows good photothermal conversion ability, and the AIEgen TPBM supports enhanced photoluminescence of the STNPs. The results show that the STNPs can act as PL/PA dual-modality imaging agents. The signal-to-noise (S/N) ratio in the PL modality reaches 8.7, and the imaging depth in the PA modality is 5.8 mm. The SPC10 in the STNPs can be decomposed under 90 mW cm(-2) white light irradiation in 6 h without any other additional agents. Furthermore, the STNPs are sufficient for the treatment of xenograft 4T1 tumor-bearing mice based on photothermal therapy. The nanocomposite STNPs achieve optimized dual-modality PL/PA imaging and the AIEgen-triggered in situ photodegradation of SPNs. These properties indicate the significant potential of STNPs in clinical diagnosis and noninvasive therapy.