Acoustic Tonometry Feasibility Study of a New Principle of Intraocular Pressure Measurement
Acoustic Tonometry Feasibility Study of a New Principle of Intraocular Pressure Measurement
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DOI：
10.1097/ijg.0b013e3181845661
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发表时间：
2009-04-01
影响因子：
2
通讯作者：
Goch, Gert
中科院分区：
文献类型：
--
作者：
von Freyberg, Axel;Sorg, Michael;Goch, Gert
目的：准确测量眼压(IOP)对于青光眼的发现、随访和治疗仍然是必不可少的。GlauPhon跨学科项目的目的是证明一种新的非接触眼压测量原理，用于分析眼睛的声学振荡。方法：将3只摘除的猪眼经视神经注入生理盐水。通过改变输液瓶的高度来调节眼压。扬声器关闭了圆柱形压力室的一端，另一边固定着一只眼睛。PC声卡通过产生矩形信号(20赫兹)使扬声器振荡。压力传感器记录了气室内的振荡压力。对每个眼压进行计算，以表征衰减曲线。结果：每一系列测量都显示出幅度差与眼压之间的明显依赖关系。最高信号属于低眼压水平，且随眼压升高而降低。平均声信号与眼压的相关系数达极显著水平(r=-0.98)。结论：实验验证了眼部声学振荡与眼压之间的关系。然而，为了将振荡参数转换为可靠的眼压值，构建用于临床试验的眼压测量设备，还需要进一步的开发。
Purpose: An accurate measurement of intraocular pressure (IOP) is still essential for detecting, following-up, and treating glaucoma. The objective of the interdisciplinary project GlauPhon was to prove a new noncontact tonometry principle that analyzes the acoustic oscillation of the eye.Method: Three enucleated porcine eyes were infused via the optic nerve with a saline solution. The IOP was adjusted by varying the height of the infusion bottle. A speaker closed one end of a cylindrical pressure chamber and an eye was fixed to the other side. A PC sound card induced the speaker to oscillate by generating a rectangular signal (20 Hz). A pressure sensor recorded the oscillating pressure within the chamber. For each IOP a calculation was performed that characterizes the attenuation profile.Results: Each series of measurements revealed an evident dependency between the amplitude difference and the IOP. The highest signal belonged to low IOP levels and it decreased with increasing IOP. The correlation of the mean acoustical signal with the given IOP showed a highly significant correlation coefficient (r = -0.98). As a result, the measured oscillation parameters are strongly dependent on the exerted IOPs.Conclusions: The experiments verified the presumed relation between the acoustic oscillation of the eye and the IOP. Nevertheless, further developments are necessary for converting the oscillation parameters into reliable IOP values, to construct a tonometry device for clinical trials.