Progress in the Synthesis and Bioactivity of Hexacoordinate Silicon(IV) Complexes
Progress in the Synthesis and Bioactivity of Hexacoordinate Silicon(IV) Complexes
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DOI：
10.1002/ejic.201600953
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发表时间：
2016-11-01
影响因子：
2.3
通讯作者：
Meggers, Eric
中科院分区：
文献类型：
--
作者：
Henker, Jens;Wirmer-Bartoschek, Julia;Meggers, Eric
（Arenediolato）双（聚吡啶基）硅（IV）络合物含有六配位硅并且令人惊讶地对水中的水解稳定。在一项正在进行的研究计划中，我们的目标是利用它们作为新的结构模板来设计生物活性化合物。作为以前工作的后续，在这里，我们提出了我们的进展，在合成六配位硅配合物的富电子邻苯二酚配体的选择性邻位双硝化，然后还原成二胺和缩合，无论是与1，2-二酮或醛。结合表位的一些代表性的复合物G-四链体DNA确定的NMR光谱滴定。
(Arenediolato)bis(polypyridyl)silicon(IV) complexes contain hexacoordinate silicon and are surprisingly stable against hydrolysis in water. In an ongoing research program, we are aiming to exploit them as new structural templates for the design of bioactive compounds. As a follow-up to previous work, here we present our progress in the synthesis of hexacoordinate silicon complexes by selective ortho-double nitration of the electron-rich catecholato ligand, followed by reduction to diamines and condensation either with 1,2-diketones or with aldehydes. Binding epitopes of some representative complexes to G-quadruplex DNA as determined by NMR spectroscopic titration are presented.