Cytomegalovirus-associated transverse myelitis in a non-immunocompromised patient
Cytomegalovirus-associated transverse myelitis in a non-immunocompromised patient
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DOI：
10.1038/sj.sc.3101265
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发表时间：
2002-03-01
期刊：
影响因子：
2.2
通讯作者：
Milonas, I
中科院分区：
文献类型：
--
作者：
Karacostas, D;Christodoulou, C;Milonas, I
设计图：单一病例报告。目的：报告1例罕见的巨细胞病毒（CMV）相关性横肌萎缩（TM）的免疫活性host.Settings：希腊的神经学和放射学大学部门和塞浦路斯的分子病毒学部门之间的合作。患者：一名16岁的男性学生开发了一个急性发热性疾病后不久TM，导致截瘫超过24小时。临床症状迅速改善，2个月内完全康复。广泛的实验室检查排除了TM的其他可能原因，没有显示免疫功能低下状态的证据。抗病毒血清学数据，通过聚合酶链反应和序列脊髓磁共振成像结果的病毒基因组鉴定，支持诊断CMV相关TM在非immunocomposedpatient.Conclusions：我们的情况下进一步表明，CMV感染应包括在TM的病因不明的鉴别诊断，在免疫功能正常的患者。临床、免疫学和神经影像学结果表明，感染后免疫介导的炎症似乎是本例最可能的发病机制。
Design: Single case report.Objective: To report a rare case of cytomegalovirus (CMV)-associated transverse myelitis (TM) in the immunocompetent host.Settings: Collaboration between a Neurology and Radiology University Department in Greece and a Molecular Virology Department in Cyprus.Patient: A 16-year-old male student developed an acute febrile illness followed shortly by TM, that resulted in paraplegia over 24 h. Rapid clinical improvement was followed by complete recovery in 2 months. Extensive laboratory work-up excluded other possible causes of TM and showed no evidence of an immunocompromised state. Antiviral serological data, identification of the viral genome by polymerase chain reaction and serial spinal cord magnetic resonance imaging findings, supported the diagnosis of CMV-associated TM in a non-immunocompromised patient.Conclusions: Our case further indicates that CMV infection should be included in the differential diagnosis of TM of uncertain etiology, in the immunocompetent patient. Clinical, immunological and neuroimaging findings indicate that post-infectious immune mediated inflammation, seems the most probable pathogenetic mechanism in this case.