Diffuse alveolar damage and thrombotic microangiopathy are the main histopathological findings in lung tissue biopsy samples of COVID-19 patients.
Diffuse alveolar damage and thrombotic microangiopathy are the main histopathological findings in lung tissue biopsy samples of COVID-19 patients.
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DOI：
10.1016/j.prp.2020.153228
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发表时间：
2020-10
期刊：
影响因子：
--
通讯作者：
Rafiezadeh A
中科院分区：
文献类型：
--
作者：
Sadegh Beigee F;Pourabdollah Toutkaboni M;Khalili N;Nadji SA;Dorudinia A;Rezaei M;Askari E;Farzanegan B;Marjani M;Rafiezadeh A
自2019年12月新型冠状病毒病（COVID-19）爆发以来，有限的研究调查了感染严重急性呼吸综合征冠状病毒2（SARS-CoV-2）患者的组织病理学结果。本研究对31名因COVID-19在伊朗德黑兰一家三级医院住院的已故患者进行了研究。从死者的肺和肝中共获得52个死后组织活检样本。评价了临床特征、实验室数据和显微镜特征。采用逆转录聚合酶链反应（RT-PCR）检测鼻咽拭子和组织活检标本中的SARS-CoV-2。死亡患者的中位年龄为66岁（范围：30-87岁），25例死亡患者（81%）为男性。从症状发作到死亡的平均间隔时间为13天（范围，6-34天）。在肺标本的组织病理学检查中，弥漫性肺泡损伤和血栓性微血管病是最常见的发现（分别为80%和60%）。肝脏主要表现为大泡性脂肪变性、门脉淋巴浆细胞性炎症和被动充血。在任何标本中均未观察到明确的病毒包涵体。此外，92%的肺组织样本经RT-PCR检测为SARS-CoV-2阳性。需要进一步研究SARS-CoV-2是否会导致人体各器官的直接细胞病变。
Since the outbreak of the novel coronavirus disease-2019 (COVID-19) in December 2019, limited studies have investigated the histopathologic findings of patients infected with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). This study was conducted on 31 deceased patients who were hospitalized for COVID-19 in a tertiary hospital in Tehran, Iran. A total of 52 postmortem tissue biopsy samples were obtained from the lungs and liver of decedents. Clinical characteristics, laboratory data, and microscopic features were evaluated. Reverse transcription polymerase chain reaction (RT-PCR) assay for SARS-CoV-2 was performed on specimens obtained from nasopharyngeal swabs and tissue biopsies. The median age of deceased patients was 66 years (range, 30–87 years) and 25 decedents (81 %) were male. The average interval from symptom onset to death was 13 days (range, 6–34 days). On histopathologic examination of the lung specimens, diffuse alveolar damage and thrombotic microangiopathy were the most common findings (80 % and 60 %, respectively). Liver specimens mainly showed macrovesicular steatosis, portal lymphoplasmacytic inflammation and passive congestion. No definitive viral inclusions were observed in any of the specimens. In addition, 92 % of lung tissue samples tested positive for SARS-CoV-2 by RT-PCR. Further studies are needed to investigate whether SARS-CoV-2 causes direct cytopathic changes in various organs of the human body.
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影响因子：
38.9
作者：
Lorente, Jose A.;Cardinal-Fernandez, Pablo;Thompson, Taylor B.
通讯作者：
Thompson, Taylor B.
DOI：
10.1016/j.cmi.2020.07.016
发表时间：
2020-12
期刊：
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases
影响因子：
--
作者：
Langford BJ;So M;Raybardhan S;Leung V;Westwood D;MacFadden DR;Soucy JR;Daneman N
通讯作者：
Daneman N
影响因子：
8.3
作者：
Cardinal-Fernandez, Pablo;Lorente, Jose A.;Matute-Bello, Gustavo
通讯作者：
Matute-Bello, Gustavo
影响因子：
158.5
作者：
Ackermann, Maximilian;Verleden, Stijn E.;Jonigk, Danny
通讯作者：
Jonigk, Danny
影响因子：
9.6
作者：
Cardinal-Fernandez, Pablo;Bajwa, Ednan K.;Thompson, B. Taylor
通讯作者：
Thompson, B. Taylor