EARLY SIGNALS IN THE MITOGENIC RESPONSE
EARLY SIGNALS IN THE MITOGENIC RESPONSE
复制标题
DOI：
10.1126/science.3018928
复制
发表时间：
1986-10-10
期刊：
影响因子：
56.9
通讯作者：
ROZENGURT, E
中科院分区：
文献类型：
--
作者：
ROZENGURT, E
多肽生长因子、调节肽和多种单独或协同作用的药理学试剂在培养的成纤维细胞中诱导有丝分裂。这些细胞外因子促进的细胞膜、细胞质和细胞核中的早期信号，连同它们的促有丝分裂作用，被整合在成纤维细胞生长调节的统一假设中。
Polypeptide growth factors, regulatory peptides, and a variety of pharmacological agents acting alone or synergistically induce mitogenesis in cultured fibroblasts. The early signals in the membrane, cytosol, and nucleus promoted by these extracellular factors, together with their mitogenic effectiveness, are integrated in a unified hypothesis for the regulation of fibroblast growth.