Age and retinal nerve fiber layer thickness measured by spectral domain optical coherence tomography.
Age and retinal nerve fiber layer thickness measured by spectral domain optical coherence tomography.
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DOI：
10.3341/kjo.2012.26.3.163
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发表时间：
2012-06
影响因子：
--
通讯作者：
Kim YY
中科院分区：
文献类型：
--
作者：
Lee JY;Hwang YH;Lee SM;Kim YY
评价健康韩国受试者年龄与Cirrus高清晰度（HD）光谱域光学相干断层扫描（OCT）测量的视乳头周围视网膜神经纤维层（RNFL）厚度之间的相关性。来自155名健康韩国受试者（年龄范围，20至79岁）的302只眼睛使用Cirrus HD-OCT进行RNFL厚度测量。使用线性混合效应模型分析年龄方面的平均、象限和时钟小时RNFL厚度参数。RNFL的平均斜率为每十年-2.1 µm（p < 0.001）。在象限分析中，上级（-3.4 µm/decade，p < 0.001）和下级（-2.9 µm/decade，p < 0.001）象限显示斜率较陡，而颞侧（-1.1 µm/decade，p < 0.001）和鼻侧（-1.0 µm/decade，p < 0.001）象限显示斜率较浅。在12个时钟小时部门中，时钟小时6（-4.5 µm/decade，p < 0.001）和1（-4.1 µm/十年，p < 0.001）显示出随年龄增长而下降的最大趋势; 3（-0.2 µm/decade，p = 0.391）和4（-0.6 µm/decade，p = 0.052）点钟方向的RNFL没有显示出显著的衰减。RNFL厚度与年龄有关，尤其是在上级和下部区域。年龄与RNFL厚度相关性的地形分布不均匀。
To evaluate the association between age and peripapillary retinal nerve fiber layer (RNFL) thickness measured by Cirrus high-definition (HD) spectral domain optical coherence tomography (OCT) in healthy Korean subjects. A total of 302 eyes from 155 healthy Korean subjects (age range, 20 to 79 years) underwent RNFL thickness measurements using the Cirrus HD-OCT. Average, quadrant, and clock-hour RNFL thickness parameters were analyzed in terms of age using linear mixed effect models. Average RNFL demonstrated a slope of -2.1 µm per decade of age (p < 0.001). In quadrant analysis, superior (-3.4 µm/decade, p < 0.001) and inferior (-2.9 µm/decade, p < 0.001) quadrants showed steeper slopes, whereas temporal (-1.1 µm/decade, p < 0.001) and nasal (-1.0 µm/decade, p < 0.001) quadrants revealed shallower slopes. Among the 12 clock-hour sectors, clock hours 6 (-4.5 µm/decade, p < 0.001) and 1 (-4.1 µm/decade, p < 0.001) showed the greatest tendency to decline with age; RNFLs of the 3 (-0.2 µm/decade, p = 0.391) and 4 (-0.6 µm/decade, p = 0.052) o'clock hour sectors did not show significant decay. RNFL thickness was associated with age, especially in superior and inferior areas. The topographic distribution of correlation between age and RNFL thickness was not uniform.