Assessing the effects of caffeine and theanine on the maintenance of vigilance during a sustained attention task
Assessing the effects of caffeine and theanine on the maintenance of vigilance during a sustained attention task
复制标题
DOI：
10.1016/j.neuropharm.2012.01.020
复制
发表时间：
2012-06-01
影响因子：
4.7
通讯作者：
Kelly, Simon P.
中科院分区：
文献类型：
--
作者：
Foxe, John J.;Morie, Kristen P.;Kelly, Simon P.
咖啡因和L-茶氨酸，都是天然存在于茶中的，会影响对空间位置进行快速阶段性注意力部署的能力，这反映在行为表现和α波段振荡大脑活动（8-14 Hz）中。然而，令人惊讶的是，人们对这些化合物如何影响注意力的一个方面知之甚少，这一方面与茶有关，即警惕注意力：在长时间内保持专注于单调任务的能力。27名参与者在四天的每一天进行了两小时的持续注意力反应任务（SART），在此期间，他们以双盲，随机，交叉的方式给予咖啡因（50 mg），茶氨酸（100 mg），组合或安慰剂。同时，我们通过高密度脑电图（EEG）记录振荡脑活动。我们询问是否单独使用化合物或两者结合使用，会在随时间推移降低错误率方面影响任务的表现，以及α-波段活动的变化是否会显示与这种表现变化的关系。当用安慰剂治疗时，参与者显示错误率上升，这种模式通常随着任务时间的增加而观察到，而在摄入咖啡因和茶氨酸后，错误率显着降低。联合治疗没有赋予任何额外的益处超过单独的任一化合物，表明单独的化合物可以在所用剂量下赋予最大的益处。摄入咖啡因后，α波段振荡活动显著降低，特别是在第一个小时。在联合处理中加入茶氨酸并没有改变这种效果。单独的茶氨酸不影响α-带活性。(C)2012爱思唯尔有限公司保留所有权利。
Caffeine and L-theanine, both naturally occurring in tea, affect the ability to make rapid phasic deployments of attention to locations in space as reflected in behavioural performance and alpha-band oscillatory brain activity (8-14 Hz). However, surprisingly little is known about how these compounds affect an aspect of attention that has been more popularly associated with tea, namely vigilant attention: the ability to maintain focus on monotonous tasks over protracted time-periods. Twenty-seven participants performed the Sustained Attention to Response Task (SART) over a two-hour session on each of four days, on which they were administered caffeine (50 mg), theanine (100 mg), the combination, or placebo in a double-blind, randomized, cross-over fashion. Concurrently, we recorded oscillatory brain activity through high-density electroencephalography (EEG). We asked whether either compound alone, or both in combination, would affect performance of the task in terms of reduced error rates overtime, and whether changes in alpha-band activity would show a relationship to such changes in performance. When treated with placebo, participants showed a rise in error rates, a pattern that is commonly observed with increasing time-on-task, whereas after caffeine and theanine ingestion, error rates were significantly reduced. The combined treatment did not confer any additional benefits over either compound alone, suggesting that the individual compounds may confer maximal benefits at the dosages employed. Alpha-band oscillatory activity was significantly reduced on ingestion of caffeine, particularly in the first hour. This effect was not changed by addition of theanine in the combined treatment. Theanine alone did not affect alpha-band activity. (C) 2012 Elsevier Ltd. All rights reserved.