Chemistry and biology of spin-trapping radicals associated with halocarbon metabolism in vitro and in vivo.
Chemistry and biology of spin-trapping radicals associated with halocarbon metabolism in vitro and in vivo.
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DOI：
10.1289/ehp.8564151
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发表时间：
1985-12
影响因子：
10.4
通讯作者：
McCay PB
中科院分区：
文献类型：
--
作者：
Janzen EG;Stronks HJ;Dubose CM;Poyer JL;McCay PB
介绍并讨论了自旋捕获方法。综述了氮氧化合物和硝酮的一些化学。概述了氮氧自由基ESR谱的模式识别。控制超精细分裂常数的大小的因素提到。列出了指定自旋加合物的方法。参考文献中的综述文章。结果在电化学还原卤代烃和一些平行超氧化物化学显示。各种猜测的反应。本文综述了用自旋捕集法检测卤代烃自由基的体内外实验，并报道了一些新的结果。添加了不同动物的比较。
The spin-trapping method is introduced and discussed. Some chemistry of nitroxides and nitrones is reviewed. Pattern recognition of ESR spectra of nitroxides is outlined. Factors controlling the magnitude of hyperfine splitting constants are mentioned. Methods of assigning spin adducts are listed. Review articles in the literature are referenced. Results in the electrochemical reduction of halocarbons are presented and some parallels with superoxide chemistry shown. Various speculative reactions are given. The in vitro and in vivo experiments where halocarbon radicals have been detected by spin trapping are reviewed and some new results reported. A comparison for different animals is added.