Repeated blood pressure measurements in a sample of Swedish twins: heritabilities and associations with polymorphisms in the renin-angiotensin-aldosterone system
Repeated blood pressure measurements in a sample of Swedish twins: heritabilities and associations with polymorphisms in the renin-angiotensin-aldosterone system
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DOI：
10.1097/00004872-200208000-00017
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发表时间：
2002-08-01
影响因子：
4.9
通讯作者：
Pedersen, NL
中科院分区：
文献类型：
--
作者：
Iliadou, A;Lichtenstein, P;Pedersen, NL
背景双胞胎和家族研究表明，遗传效应可以解释较高程度的血压表型变异。然而，许多研究未能复制特定基因与舒张压和收缩压之间的关联。方法在结构方程建模框架中，作者调查了瑞典双胞胎登记处基于人口的298对同性双胞胎样本重复测量血压的纵向变化。同时用Fulker检验分析血压与血管紧张素转换酶和血管紧张素11型受体1型多态的关系。同时进行连锁和关联检验，揭示该多态是数量性状基因座(QTL)还是与QTL连锁不平衡。结果遗传影响可解释舒张压表型变异的46%和收缩压表型变异的63%。随着时间的推移，遗传影响是稳定的，并且在舒张压和收缩压的表型相关性中贡献了78%。非共享环境效应的特征是特定于时间的影响和从一个时间点到下一个时间点的很少传播。结论在成年后6年内，舒张压和收缩压都有相当大的遗传稳定性。非共享的环境影响具有较小的长期影响，尽管与多态的关联不能被复制，但出于功率考虑，应谨慎地解释结果。(C)2002年，里平科特·威廉姆斯·威尔金斯。
Background Twin and family studies have shown that genetic effects explain a relatively high amount of the phenotypic variation in blood pressure. However, many studies have not been able to replicate findings of association between specific polymorphisms and diastolic and systolic blood pressure.Methods In a structural equation-modelling framework the authors investigated longitudinal changes in repeated measures of blood pressures in a sample of 298 like-sexed twin pairs from the population-based Swedish Twin Registry. Also examined was the association between blood pressure and polymorphisms in the angiotensin-I converting enzyme and the angiotensin 11 receptor type 1 with the 'Fulker' test Both linkage and association were tested simultaneously revealing whether the polymorphism is a Quantitative Trait Locus (QTL) or in linkage disequilibrium with the QTL.Results Genetic influences explained up to 46% of the phenotypic variance in diastolic and 63% of the phenotypic variance in systolic blood pressure. Genetic influences were stable over time and contributed up to 78% of the phenotypic correlation in both diastolic and systolic blood pressure. Non-shared environmental effects were characterised by time specific influences and little transmission from one time point to the next. There was no significant linkage and association between the polymorphisms and blood pressure.Conclusions There is a considerable genetic stability in both diastolic and systolic blood pressure for a 6-year period of time in adult life. Non-shared environmental influences have a small long-term effect Although associations with the polymorphisms could not be replicated, results should be interpreted with caution due to power considerations. (C) 2002 Lippincott Williams Wilkins.