Evidence for Structural and Functional Damage of the Inner Retina in Diabetes With No Diabetic Retinopathy.
Evidence for Structural and Functional Damage of the Inner Retina in Diabetes With No Diabetic Retinopathy.
复制标题
无糖尿病视网膜病变的糖尿病患者眼内视网膜存在结构和功能损害的证据 。
DOI：
10.1167/iovs.62.3.35
复制
发表时间：
2021-03-01
影响因子：
4.4
通讯作者：
Hogg RE
中科院分区：
文献类型：
--
作者：
Montesano G;Ometto G;Higgins BE;Das R;Graham KW;Chakravarthy U;McGuiness B;Young IS;Kee F;Wright DM;Crabb DP;Hogg RE
提供糖尿病患者血管改变前视网膜内层丢失的结构和功能证据，并在已建立的神经模型的背景下解释结构-功能关系。来自505名参与者的一只眼睛的数据（134名糖尿病患者，没有临床上明显的视网膜血管改变）被包括在该分析中。这些数据是作为一项大型人群研究的一部分收集的。功能测试包括最佳矫正视力、Pelli-Robson对比敏感度、中间视觉微视野检查和倍频技术视野检查（FDT）。收集所有参与者的黄斑光学相干断层扫描体积扫描。为了解释神经模型背景下的结构-功能关系，将神经节细胞层（GCL）厚度转换为局部神经节细胞（GC）计数。糖尿病组GCL和内网状层明显变薄（P < 0.05），黄斑视网膜神经纤维层和外层视网膜无明显差异。糖尿病患者除微视野检查外，其他各项功能检查均明显下降（P < 0.05）。FDT和微视野检查均显示与GC计数显著相关（P < 0.05），与部分总和条件下神经模型的预测一致。然而，FDT捕获了结构损失无法解释的额外显著损伤（P = 0.03）。功能和结构测量支持糖尿病早期神经元丢失。结构-功能关系遵循已建立的神经模型的预测。可以改进功能测试，以在黄斑的总总和条件下操作，对早期丧失变得更敏感。
To provide structural and functional evidence of inner retinal loss in diabetes prior to vascular changes and interpret the structure-function relationship in the context of an established neural model. Data from one eye of 505 participants (134 with diabetes and no clinically evident vascular alterations of the retina) were included in this analysis. The data were collected as part of a large population-based study. Functional tests included best-corrected visual acuity, Pelli-Robson contrast sensitivity, mesopic microperimetry, and frequency doubling technology perimetry (FDT). Macular optical coherence tomography volume scans were collected for all participants. To interpret the structure-function relationship in the context of a neural model, ganglion cell layer (GCL) thickness was converted to local ganglion cell (GC) counts. The GCL and inner plexiform layer were significantly thinner in participants with diabetes (P < 0.05), with no significant differences in the macular retinal nerve fiber layer or the outer retina. All functional tests except microperimetry showed a significant loss in diabetic patients (P < 0.05). Both FDT and microperimetry showed a significant relationship with the GC count (P < 0.05), consistent with predictions from a neural model for partial summation conditions. However, the FDT captured additional significant damage (P = 0.03) unexplained by the structural loss. Functional and structural measurements support early neuronal loss in diabetes. The structure-function relationship follows the predictions from an established neural model. Functional tests could be improved to operate in total summation conditions in the macula, becoming more sensitive to early loss.
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DOI：
10.1016/s0896-1549(03)00011-7
发表时间：
2003-06-01
期刊：
Ophthalmology clinics of North America
影响因子：
--
作者：
Anderson, Andrew J;Johnson, Chris A
通讯作者：
Johnson, Chris A
影响因子：
8.2
作者：
Bengtsson, B;Heijl, A;Agardh, E
通讯作者：
Agardh, E
影响因子：
4.2
作者：
Kim, Kiyoung;Kim, Eung Suk;Yu, Seung-Young
通讯作者：
Yu, Seung-Young
影响因子：
4.4
作者：
Barber, Alistair J.;Gardner, Thomas W.;Abcouwer, Steven F.
通讯作者：
Abcouwer, Steven F.
影响因子：
17.8
作者：
Hood, Donald C.;Kardon, Randy H.
通讯作者：
Kardon, Randy H.